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Chemical, spectroscopic characterization, and in vitro antibacterial studies of a new gold(I) complex with N-acetyl-L-cysteine

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dc.contributor.authorCorbi, P. P.
dc.contributor.authorQuintao, F. A.
dc.contributor.authorFerraresi, D. K. D.
dc.contributor.authorLustri, W. R.
dc.contributor.authorAmaral, A. C.
dc.contributor.authorMassabni, Antonio Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionCtr Univ Araraquara
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:31:23Z
dc.date.available2014-05-20T15:31:23Z
dc.date.issued2010-01-01
dc.description.abstractA new gold(I) complex with N-acetyl-L-cysteine was synthesized and characterized by chemical and spectroscopic techniques. The elemental and thermal analyses of the solid compound fit to the composition AuC5H8NO3S center dot 0.75H2O. Solid-state 13C-nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Au(I) through sulfur. The insolubility of the complex in both polar and non-polar solvents supports a polymeric structure. The antibacterial activity of the complex was evaluated by antibiogram assays using the disc diffusion method. The compound showed effective antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative) bacterial cells.en
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Lab Quim Bioinorgan & Med, Inst Quim, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationCtr Univ Araraquara, Assoc Sao Bento Ensino, BR-14801320 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Quim Geral & Inorgan, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Quim Geral & Inorgan, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 08/54290-1
dc.description.sponsorshipIdFAPESP: 08/54291-8
dc.description.sponsorshipIdFAPESP: 06/55367-2
dc.format.extent1390-1397
dc.identifierhttp://dx.doi.org/10.1080/00958971003782608
dc.identifier.citationJournal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 63, n. 8, p. 1390-1397, 2010.
dc.identifier.doi10.1080/00958971003782608
dc.identifier.issn0095-8972
dc.identifier.urihttp://hdl.handle.net/11449/40529
dc.identifier.wosWOS:000277737700011
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.ispartofjcr1.703
dc.relation.ispartofsjr0,371
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectGold(I)en
dc.subjectN-acetyl-L-cysteineen
dc.subjectInfrared spectroscopyen
dc.subjectNMR spectroscopyen
dc.subjectAntibacterial activityen
dc.titleChemical, spectroscopic characterization, and in vitro antibacterial studies of a new gold(I) complex with N-acetyl-L-cysteineen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Inorgânica - IQARpt

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Araraquara - IQAR - Instituto de Química