Inhibitors of human collagenase, MMP1
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Different common drugs (Meloxicam, Tenoxicam and Piroxicam, and sodium alendronate) were tested both experimental and theoretically as inhibitors of interstitial human collagenase, also known as matrix metalloproteinase 1 (MMP-1). The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by the reaction with a fluorescent synthetic substrate and measuring the change of emission. Collagenase-inhibitor interaction was studied theoretically by computational calculations. Three among the four tested substances showed moderate inhibiting activity against the human collagenase.
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Collagenase, Docking, Human metalloproteinases, Inhibitors, MMP-1
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Inglês
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Ecletica Quimica, v. 34, n. 4, p. 87-102, 2009.
