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Inactivation of Equine Arteritis Virus by Indolicidin Peptide

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dc.contributor.authorMetz, Germán Ernesto
dc.contributor.authorAzcurra, Miriam Beatriz
dc.contributor.authorde Souza, Guilherme Sastre
dc.contributor.authorde Arruda Brasil, Maria Carolina Oliveira [UNESP]
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorLorenzón, Esteban Nicolás
dc.contributor.institutionNational University of La Plata
dc.contributor.institutionCONICET-CCT La Plata
dc.contributor.institutionFederal University of Jataí
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2025-04-29T19:33:32Z
dc.date.issued2025-05-01
dc.description.abstractEquine viral arteritis is an economically important contagious disease caused by equine arteritis virus (EAV). Our objective was to evaluate the antiviral activity of indolicidin and K-indolicidin peptides against EAV. We found that indolicidin, but not K-indolicidin, completely inhibits EAV. Furthermore, indolicidin did not affect sperm quality parameters, the primary source of EAV transmission. This is the first report showing the potential of indolicidin as a candidate for use as a therapeutic agent against EAV and an additive in equine semen extenders.en
dc.description.affiliationLaboratory of Virology Faculty of Veterinary Sciences National University of La Plata
dc.description.affiliationCONICET-CCT La Plata
dc.description.affiliationAnimal Reproduction Research Institute Faculty of Veterinary Sciences National University of La Plata
dc.description.affiliationInstitute of Health Sciences Federal University of Jataí, Goiás
dc.description.affiliationSão Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Chemistry
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFacultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata
dc.description.sponsorshipFacultad de Ciencias Exactas, Universidad Nacional de La Plata
dc.description.sponsorshipUniversidad Nacional de La Plata
dc.description.sponsorshipIdFAPESP: 22/05411-8
dc.description.sponsorshipIdCNPq: 427961/2018-1
dc.description.sponsorshipIdFacultad de Ciencias Astronómicas y Geofísicas, Universidad Nacional de La Plata: V301
dc.description.sponsorshipIdFacultad de Ciencias Exactas, Universidad Nacional de La Plata: V301
dc.description.sponsorshipIdUniversidad Nacional de La Plata: V301
dc.identifierhttp://dx.doi.org/10.1007/s10989-025-10698-y
dc.identifier.citationInternational Journal of Peptide Research and Therapeutics, v. 31, n. 3, 2025.
dc.identifier.doi10.1007/s10989-025-10698-y
dc.identifier.issn1573-3904
dc.identifier.issn1573-3149
dc.identifier.scopus2-s2.0-86000022048
dc.identifier.urihttps://hdl.handle.net/11449/303977
dc.language.isoeng
dc.relation.ispartofInternational Journal of Peptide Research and Therapeutics
dc.sourceScopus
dc.subjectAntiviral activity
dc.subjectEquine arteritis virus
dc.subjectIndolicidin
dc.titleInactivation of Equine Arteritis Virus by Indolicidin Peptideen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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Araraquara - IQAR - Instituto de Química