Logotipo do repositório
 

Publicação:
Influence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic medium

Página do item simplificado
dc.contributor.authorTrovatti, Eliane [UNESP]
dc.contributor.authorBadino Jr., Alberto Colli
dc.contributor.authorHokka, Carlos Osamu
dc.contributor.authorAraujo, Maria Lucia Gonsales Da Costa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2022-04-28T20:08:49Z
dc.date.available2022-04-28T20:08:49Z
dc.date.issued2006-09-20
dc.description.abstractThe effect of nitrogen source on clavulanic acid production was investigated in shake flasks. Media containing asparagine plus one of several different amino acids or a combination of two amino acids was tested. The best result, ca. 180 mg/L clavulanic acid, CA, in 60 h, was obtained with the lysine-tyrosine pair. In an aerated and agitated fermentor this medium led to CA concentrations of ca. 210 mg/L, a remarkable production for synthetic medium utilization. Amino acids analysis during cultivation indicated that, while asparagine was consumed rapidly, lysine and tyrosine were metabolized slowly, promoting CA production.en
dc.description.affiliationUNESP Instituto de Quimica Departamento de Bioquímica e Tecnologia Química, C. P. 355, 14801-970, Araraquara - SP
dc.description.affiliationUFSCar Departamento de Engenharia Química, C. P. 676, 13565-905, São Carlos - SP
dc.description.affiliationUnespUNESP Instituto de Quimica Departamento de Bioquímica e Tecnologia Química, C. P. 355, 14801-970, Araraquara - SP
dc.format.extent173-179
dc.identifier.citationBrazilian Archives of Biology and Technology, v. 49, n. SPEC. ISS., p. 173-179, 2006.
dc.identifier.issn1516-8913
dc.identifier.scopus2-s2.0-33748642778
dc.identifier.urihttp://hdl.handle.net/11449/224800
dc.language.isoeng
dc.relation.ispartofBrazilian Archives of Biology and Technology
dc.sourceScopus
dc.subjectAmino acids
dc.subjectB-lactamase inhibitor
dc.subjectClavulanic acid
dc.subjectS. clavuligerus
dc.subjectSynthetic medium
dc.titleInfluence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic mediumen
dc.typeTrabalho apresentado em evento
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

Arquivos

Coleções

Araraquara - IQAR - Instituto de Química