Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate
| dc.contributor.author | Leoncio, T. O.L. | |
| dc.contributor.author | Fernandes, A. S. | |
| dc.contributor.author | Felzenszwalb, I. | |
| dc.contributor.author | Araujo-Lima, C. F. | |
| dc.contributor.author | Oliveira, D. P. [UNESP] | |
| dc.contributor.author | Dorta, D. J. [UNESP] | |
| dc.contributor.author | Sampaio, C. F. | |
| dc.contributor.author | Ferraz, E. R.A. [UNESP] | |
| dc.contributor.institution | Federal Fluminense University | |
| dc.contributor.institution | State University of Rio de Janeiro | |
| dc.contributor.institution | Federal University of the State of Rio de Janeiro | |
| dc.contributor.institution | Universidade de São Paulo (USP) | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.date.accessioned | 2025-04-29T18:48:34Z | |
| dc.date.issued | 2024-11-01 | |
| dc.description.abstract | Flame retardants, crucial for fire prevention, are used worldwide, but they are considered to be ‘emerging contaminants’ and may pose risks to human and environmental health. Aluminum diethyl phosphinate (ALPI) is a halogen-free flame retardant. To evaluate the toxicity of this compound, the following assays were performed: Salmonella/microsome mutagenicity assay; toxicity assays with two endpoints (mitochondrial dehydrogenase activity, plasma membrane integrity); micronucleus assay with human hepatoma cell line HepG2. ALPI was not mutagenic in Salmonella strains TA97, TA98, TA100, TA102, or TA104. ALPI was not cytotoxic at any concentration tested. The HepG2 micronucleus assay showed genotoxicity of ALPI at 200 µg/mL and no cytotoxicity (cytokinesis-block proliferation index, CBPI). Our data are relevant to the regulation of flame retardants. | en |
| dc.description.affiliation | School of Pharmacy Federal Fluminense University, RJ | |
| dc.description.affiliation | Department of Biophysics and Biometrics Roberto Alcantara Gomes Biology Institute State University of Rio de Janeiro | |
| dc.description.affiliation | Department of Genetics and Molecular Biology Federal University of the State of Rio de Janeiro | |
| dc.description.affiliation | University of São Paulo Ribeirão Preto, SP | |
| dc.description.affiliation | National Institute for Alternative Technologies for the Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) UNESP Institute of Chemistry, SP | |
| dc.description.affiliationUnesp | National Institute for Alternative Technologies for the Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) UNESP Institute of Chemistry, SP | |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
| dc.description.sponsorshipId | CNPq: 302345/2017-5 | |
| dc.identifier | http://dx.doi.org/10.1016/j.mrgentox.2024.503829 | |
| dc.identifier.citation | Mutation Research - Genetic Toxicology and Environmental Mutagenesis, v. 900. | |
| dc.identifier.doi | 10.1016/j.mrgentox.2024.503829 | |
| dc.identifier.issn | 1879-3592 | |
| dc.identifier.issn | 1383-5718 | |
| dc.identifier.scopus | 2-s2.0-85208180659 | |
| dc.identifier.uri | https://hdl.handle.net/11449/300086 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | |
| dc.source | Scopus | |
| dc.subject | Emerging contaminants | |
| dc.subject | In vitro assays | |
| dc.subject | Toxicity | |
| dc.title | Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate | en |
| dc.type | Artigo | pt |
| dspace.entity.type | Publication | |
| relation.isOrgUnitOfPublication | bc74a1ce-4c4c-4dad-8378-83962d76c4fd | |
| relation.isOrgUnitOfPublication.latestForDiscovery | bc74a1ce-4c4c-4dad-8378-83962d76c4fd | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara | pt |