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Biochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venom

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dc.contributor.authorMurakami, Mário T. [UNESP]
dc.contributor.authorLourenzoni, Marco R.
dc.contributor.authorArruda, Emerson Z.
dc.contributor.authorTomaz, Marcelo A.
dc.contributor.authorViçoti, Magno M. [UNESP]
dc.contributor.authorAbrego, José R. B. [UNESP]
dc.contributor.authorMelo, Paulo A.
dc.contributor.authorArni, Raghuvir K. [UNESP]
dc.contributor.institutionLNLS
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAssociated Researcher
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionButantan Institute
dc.date.accessioned2022-04-28T20:44:02Z
dc.date.available2022-04-28T20:44:02Z
dc.date.issued2008-09-01
dc.description.abstractBothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation. In order to elucidate the structural determinants of its multiple pharmacological activities, we have studied the effects of suramin on Bothropstoxin-II and present details concerning the mode of binding. © 2008 Bentham Science Publishers Ltd.en
dc.description.affiliationCenter for Structural Molecular Biology Brazilian Synchrotron Light Laboratory LNLS, Campinas, SP
dc.description.affiliationCenter for Structural and Molecular Biology Department of Physics IBILCE/UNESP, São José do Rio Preto, SP
dc.description.affiliationAssociated Researcher, São Carlos, SP
dc.description.affiliationDepartment of Basic and Clinical Pharmacology ICB UFRJ, RJ
dc.description.affiliationCenter for Applied Toxinology Butantan Institute, São Paulo, SP
dc.description.affiliationDepartment of Physics IBILCE/UNESP, Cristovão Colombo 2265, São José do Rio Preto, SP, 15054-000
dc.description.affiliationUnespCenter for Structural and Molecular Biology Department of Physics IBILCE/UNESP, São José do Rio Preto, SP
dc.description.affiliationUnespDepartment of Physics IBILCE/UNESP, Cristovão Colombo 2265, São José do Rio Preto, SP, 15054-000
dc.format.extent1002-1008
dc.identifierhttp://dx.doi.org/10.2174/092986608785849245
dc.identifier.citationProtein and Peptide Letters, v. 15, n. 9, p. 1002-1008, 2008.
dc.identifier.doi10.2174/092986608785849245
dc.identifier.issn0929-8665
dc.identifier.scopus2-s2.0-52749091852
dc.identifier.urihttp://hdl.handle.net/11449/225292
dc.language.isoeng
dc.relation.ispartofProtein and Peptide Letters
dc.sourceScopus
dc.subjectPharmacological activities
dc.subjectPhospholipases A2
dc.subjectStructural studies
dc.subjectSuramin
dc.titleBiochemical and structural investigations of bothropstoxin-II, a myotoxic Asp49 phospholipase A2 from Bothrops jararacussu venomen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentFísica - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas