Isolated flavonoids against mammary tumour cells LM2
Loading...
External sources
External sources
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Type
Article
Access right
Acesso aberto
External sources
External sources
Abstract
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC 50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. © 2009 Verlag der Zeitschrift für Naturforschung.
Description
Keywords
Antitumour activity , Cytokine , Flavonoids , antineoplastic agent , cisplatin , flavonoid , animal , Bagg albino mouse , cell survival , drug effect , experimental neoplasm , female , isolation and purification , Malpighiaceae , mouse , Myrtaceae , pathology , tumor cell line , Animals , Antineoplastic Agents , Cell Line, Tumor , Cell Survival , Cisplatin , Female , Mammary Neoplasms, Experimental , Mice , Mice, Inbred BALB C , Byrsonima crassa , Davilla , Mouriri , Murinae , Pusa
Language
English
Citation
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 64, n. 1-2, p. 32-36, 2009.
