Publicação:
Using the comet and micronucleus assays for genotoxicity studies: a review

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dc.contributor.authorAraldi, Rodrigo Pinheiro [UNESP]
dc.contributor.authorMelo, Thatiana Corrêa de
dc.contributor.authorMendes, Thais Biude [UNESP]
dc.contributor.authorDe Sá Júnior, Paulo
dc.contributor.authorNozima, Bruno Heidi Nakano
dc.contributor.authorIto, Eliana Tiemi [UNESP]
dc.contributor.authorCarvalho, Rodrigo Franco de
dc.contributor.authorSouza, Edislane Barreiros de [UNESP]
dc.contributor.authorStocco, Rita de Cassia
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-08-21T17:54:02Z
dc.date.available2015-08-21T17:54:02Z
dc.date.issued2015
dc.description.abstractPhysical, chemical and biological agents can act in the DNA, resulting in mutation involved in cancer. Thus, genotoxic tests are required by regulatory agencies in order to evaluate potential risk of cancer. Among these tests, the comet assay (CA) and micronucleus assay (MNA) are the most commonly used. However, there are different protocols and recommendations already published. This is the first review, after the inclusion of CA in S2R1 guidance and OECD 489, which summarizes the main technical recommendations of both CA and MNA.pt
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências e Letras de Assis, Assis, Avenida Dom Antonio, 2100, Jardim Universitário, CEP 19806-900, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências e Letras de Assis, Assis, Avenida Dom Antonio, 2100, Jardim Universitário, CEP 19806-900, SP, Brasil
dc.format.extent74-82
dc.identifier.citationBiomedicine & Pharmacotherapy, v. 72, p. 74-82, 2015.
dc.identifier.doi10.1016/j.biopha.2015.04.004
dc.identifier.issn0753-3322
dc.identifier.lattes3892896473273324
dc.identifier.orcid0000-0001-7083-5626
dc.identifier.urihttp://hdl.handle.net/11449/127163
dc.language.isoeng
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.relation.ispartofjcr3.457
dc.relation.ispartofsjr0,951
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectGenotoxicity testsen
dc.subjectComet assayen
dc.subjectMicronucleus assayen
dc.subjectMutagenesisen
dc.titleUsing the comet and micronucleus assays for genotoxicity studies: a reviewen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes3892896473273324[8]
unesp.author.orcid0000-0001-7083-5626[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Letras, Assispt
unesp.departmentCiências Biológicas - FCLASpt

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