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Evaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2

dc.contributor.authorRodrigues, Caroline Fabri Bittencourt [UNESP]
dc.contributor.authorFerreira, Marcelo José Pena
dc.contributor.authorBelchor, Mariana Novo [UNESP]
dc.contributor.authorCosta, Caroline R.C. [UNESP]
dc.contributor.authorNovaes, Danielle P. [UNESP]
dc.contributor.authordos Santos, Adeilso Bispo [UNESP]
dc.contributor.authorTamayose, Cinthia I.
dc.contributor.authorPinho, Marcus Vinícius Terashima [UNESP]
dc.contributor.authorde Oliveira, Marcos Antonio [UNESP]
dc.contributor.authorToyama, Marcos Hikari [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSão Paulo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:38:46Z
dc.date.available2019-10-06T16:38:46Z
dc.date.issued2019-01-01
dc.description.abstractEllagitannins constitute the largest group of hydrolyzable tannins of plants, and, from this group, casuarictin (Casu) was identified in some plant species. However, to our knowledge, no investigation of secretory phospholipase A2 (sPLA2) inhibition by Casu has been performed yet. Casuarictin was isolated by chromatography n-butanol (n-BuOH) partition of Laguncularia racemosa leaves. The pharmacological and biological effects of Casu were evaluated on isolated sPLA2 from the rattlesnake (Crotalus durissus terrificus) and using a plant bacterial strain. The compound was able to form a protein complex consisting of a stable sPLA2 + Casu complex. Analyses carried out with matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF) revealed that the molecular mass of sPLA2 increased from 14,425.62 to 15,362.74 Da. The enzymatic activity of the sPLA2 + Casu complex was significantly lower than that of native sPLA2. Besides, molecular interactions of Casu with sPLA2 were able to virtually abolish the native edematogenic effect as well as myonecrosis induced by the protein when injected 10 min after sPLA2. Therefore, Casu may be considered a potential anti-inflammatory that can be used to treat edema and myonecrosis induced by serine-secreting phospholipase A2. In addition, the compound also showed great antimicrobial potential.en
dc.description.affiliationLaboratório de Bioquímica e Biologia Molecular de Peptídeos (BIOMOLPEP) Instituto de Biociências UNESP Campus do Litoral Paulista, São Vicente
dc.description.affiliationLaboratório de Herpetologia Instituto Butantan São Paulo
dc.description.affiliationDepartamento de Botânica Instituto de Biociências Universidade de São Paulo
dc.description.affiliationLaboratório de Biologia Molecular Estrutural (LABIMES) Instituto de Biociências UNESP Campus do Litoral Paulista, São Vicente
dc.description.affiliationUnespLaboratório de Bioquímica e Biologia Molecular de Peptídeos (BIOMOLPEP) Instituto de Biociências UNESP Campus do Litoral Paulista, São Vicente
dc.description.affiliationUnespLaboratório de Biologia Molecular Estrutural (LABIMES) Instituto de Biociências UNESP Campus do Litoral Paulista, São Vicente
dc.description.sponsorshipNational Council for Scientific Research
dc.description.sponsorshipUniversidade de São Paulo
dc.description.sponsorshipIdNational Council for Scientific Research: 001
dc.description.sponsorshipIdUniversidade de São Paulo: 2013/10938-6
dc.description.sponsorshipIdUniversidade de São Paulo: 2014/20932-8
dc.description.sponsorshipIdUniversidade de São Paulo: 2014/21593-2
dc.description.sponsorshipIdUniversidade de São Paulo: 2017/20291-0
dc.identifierhttp://dx.doi.org/10.3390/md17070403
dc.identifier.citationMarine Drugs, v. 17, n. 7, 2019.
dc.identifier.doi10.3390/md17070403
dc.identifier.issn1660-3397
dc.identifier.lattes8573195327542061
dc.identifier.scopus2-s2.0-85068595833
dc.identifier.urihttp://hdl.handle.net/11449/189380
dc.language.isoeng
dc.relation.ispartofMarine Drugs
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnti-inflammatory
dc.subjectCasuarictin
dc.subjectCrotalus durissus terrificus
dc.subjectEdema
dc.subjectEnzymatic inhibition
dc.subjectLaguncularia racemosa
dc.subjectMyonecrosis
dc.subjectSecretory phospholipase A2
dc.titleEvaluation of the Inhibitory Potential of Casuarictin, an Ellagitannin Isolated from White Mangrove (Laguncularia racemosa) Leaves, on Snake Venom Secretory Phospholipase A2en
dc.typeArtigo
dspace.entity.typePublication
unesp.advisor.lattes8573195327542061
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

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