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Initial structural analysis of an alpha(4)beta(4) C-type lectin from the venom of Crotalus durissus terrificus

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dc.contributor.authorMurakami, M. T.
dc.contributor.authorWatanabe, L.
dc.contributor.authorGava, L. M.
dc.contributor.authorZela, S. P.
dc.contributor.authorCintra, ACO
dc.contributor.authorArni, R. K.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:02:19Z
dc.date.available2014-05-20T14:02:19Z
dc.date.issued2003-10-01
dc.description.abstractConvulxin, an alphabeta C-type lectin, is a potent platelet activator isolated from the venom of the South American rattlesnake Crotalus durissus terrificus. It is a 26.5 kDa alphabeta heterodimer consisting of two homologous disulfide-linked chains. The crystals belong to space group I4, with unit-cell parameters a = b = 131.61, c = 121.85 Angstrom, and diffraction data were collected to 2.7 Angstrom. The structure was solved by molecular replacement and the asymmetric unit contains two alphabeta heterodimers, each of which forms a disulfide-linked cyclic alpha(4)beta(4) tetramer in the unit cell. These alpha(4)beta(4) tetramers are stacked to form a large solvent channel.en
dc.description.affiliationUNESP, IBILCE, Dept Phys, BR-15005400 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUSP, Fac Ciências Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Phys, BR-15005400 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent1813-1815
dc.identifierhttp://dx.doi.org/10.1107/S0907444903016202
dc.identifier.citationActa Crystallographica Section D-biological Crystallography. Copenhagen: Blackwell Munksgaard, v. 59, p. 1813-1815, 2003.
dc.identifier.dimensionspub.1021178097
dc.identifier.doi10.1107/S0907444903016202
dc.identifier.issn0907-4449
dc.identifier.issn2059-7983
dc.identifier.issn1399-0047
dc.identifier.lattes9162508978945887
dc.identifier.orcid0000-0003-2460-1145
dc.identifier.orcid0000-0002-0405-8010
dc.identifier.orcid0000-0002-5437-4038
dc.identifier.pmid14501123
dc.identifier.urihttp://hdl.handle.net/11449/21962
dc.identifier.wosWOS:000185451200018
dc.language.isoeng
dc.publisherBlackwell Munksgaard
dc.publisherInternational Union of Crystallography (IUCr)
dc.relation.ispartofActa Crystallographica Section D: Biological Crystallography
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.sourceDimensions
dc.titleInitial structural analysis of an alpha(4)beta(4) C-type lectin from the venom of Crotalus durissus terrificusen
dc.typeArtigopt
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Munksgaard
dspace.entity.typePublication
relation.isOrgUnitOfPublication43c38943-bd6f-4fb6-a9a5-8482a1f632c0
relation.isOrgUnitOfPublication.latestForDiscovery43c38943-bd6f-4fb6-a9a5-8482a1f632c0
unesp.author.lattes9162508978945887[6]
unesp.author.orcid0000-0003-2460-1145[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentFísica - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas