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Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

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dc.contributor.authorToyama, M. H. [UNESP]
dc.contributor.authorToyama, D. O.
dc.contributor.authorTorres, V. M.
dc.contributor.authorPontes, G. C.
dc.contributor.authorFarias, W. R. L.
dc.contributor.authorMelo, F. R.
dc.contributor.authorOliveira, S. C. B. [UNESP]
dc.contributor.authorFagundes, F. H. R. [UNESP]
dc.contributor.authorDiz Filho, E. B. S. [UNESP]
dc.contributor.authorCavada, B. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUFC
dc.date.accessioned2014-05-20T13:12:21Z
dc.date.available2014-05-20T13:12:21Z
dc.date.issued2010-11-01
dc.description.abstractLow molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.en
dc.description.affiliationUNESP, Sao Vicente, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, São Paulo, Brazil
dc.description.affiliationUniversidade Federal do Ceará (UFC), Dept Engn Pesca & BioMol BioMar, Fortaleza, Ceara, Brazil
dc.description.affiliationHosp Univ Clementino Fraga Filho HUCFF UFRJ, Rio de Janeiro, Brazil
dc.description.affiliationUniv Estadual Campinas, Dept Bioquim, Inst Biol, São Paulo, Brazil
dc.description.affiliationUFC, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Sao Vicente, Brazil
dc.description.sponsorshipFAPEPS
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPEPS: 54714-3
dc.description.sponsorshipIdCNPq: 558193/2009-9
dc.format.extent567-571
dc.identifierhttp://dx.doi.org/10.1007/s10930-010-9294-9
dc.identifier.citationProtein Journal. New York: Springer, v. 29, n. 8, p. 567-571, 2010.
dc.identifier.doi10.1007/s10930-010-9294-9
dc.identifier.issn1572-3887
dc.identifier.lattes8573195327542061
dc.identifier.urihttp://hdl.handle.net/11449/336
dc.identifier.wosWOS:000284644400005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofProtein Journal
dc.relation.ispartofjcr1.133
dc.relation.ispartofsjr0,451
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBotryocladia occidentalisen
dc.subjectCrotalus durissus cascavellaen
dc.subjectSecretory phospholipase A2 (sPLA2)en
dc.subjectEdemaen
dc.subjectMyonecrosisen
dc.titleEffects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavellaen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes8573195327542061
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

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São Vicente - IBCLP - Instituto de Biociências