Approach on the Electrochemical Reactivity of Poly-L-Glutamic Acid Against Doxorubicin and Its Application in the Development of a Voltammetric Sensor
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Undergraduate course
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Publisher
Electrochemical Science Group
Type
Article
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Acesso aberto
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Abstract
The poly-L-glutamic acid (PGA), was used a biodegradable polymers as conjugated to doxorubicin (DXR) and also in the modification glassy carbon electrode. The interaction operate via terminal amino groups of the drug and the side chain carboxyl groups of branched PGA film and it is the base to develop a simple voltammetric sensor for the determination of doxorubicin in human urine. The preconcentration of DXR on the modified electrode occurs under open circuit and studied by the methods of square wave voltammetry to monitor the drug. Standard curves were linear over the concentration range of 2.20 - 44.5 mu mol L(-1) giving a detection limit of 0.45 mu mol L(-1) show that the proposed sensor is suitable for doxorubicin determination in real samples.
Description
Keywords
Doxorubicin, poly-L-glutamic acid, adsorption, semiquinone free radical, urine
Language
English
Citation
International Journal of Electrochemical Science. Belgrade: Electrochemical Science Group, v. 5, n. 10, p. 1399-1410, 2010.
