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Nigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventer

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dc.contributor.authorGomes, Paulo C. [UNESP]
dc.contributor.authorde Souza, Bibiana M. [UNESP]
dc.contributor.authorDias, Nathalia B. [UNESP]
dc.contributor.authorCesar-Tognoli, Lilian M. M. [UNESP]
dc.contributor.authorSilva-Filho, Luiz C. [UNESP]
dc.contributor.authorTormena, Claudio F.
dc.contributor.authorRittner, Roberto
dc.contributor.authorRichardson, Michael
dc.contributor.authorCordeiro, Marta N.
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionFundação Ezequiel Dias (FUNED)
dc.date.accessioned2014-05-20T13:54:59Z
dc.date.available2014-05-20T13:54:59Z
dc.date.issued2011-02-01
dc.description.abstractNigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Chem, Fac Sci, São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Chem, São Paulo, Brazil
dc.description.affiliationEzequiel Dias Fdn FUNED, Ctr Res & Dev, Belo Horizonte, MG, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Chem, Fac Sci, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipINCT-Imunologia
dc.description.sponsorshipIdFAPESP: 04/07942-2
dc.description.sponsorshipIdFAPESP: 06/57122-6
dc.description.sponsorshipIdCNPq: 472870/2004-1
dc.format.extent266-274
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2010.11.021
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.
dc.identifier.doi10.1016/j.toxicon.2010.11.021
dc.identifier.fileWOS000287629400010.pdf
dc.identifier.issn0041-0101
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19670
dc.identifier.wosWOS:000287629400010
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSpider venomen
dc.subjectSpectroscopyen
dc.subjectLow molecular massen
dc.subjectNeurotoxinen
dc.subjectGlutamate receptoren
dc.subjectNatural producten
dc.titleNigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventeren
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0001-6674-2160[5]

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Rio Claro - CEIS - Centro de Estudos de Insetos Sociais