Publicação: Rietveld method in the analysis of polymorphism in mebendazole tablets acquired in Brazil's drugstores
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Mebendazole (MBZ) is an anthelmintic medicine known to exhibit the polymorphs A, B and C, where polymorph C is the one indicated for tablets. Mebendazole commercial tablets (references, generics and similars) were analyzed in this work using X-ray powder diffraction data and the Rietveld method (RM) aiming at characterizing and quantifying crystal phases. Form C was found in mixture with form A in formulations of 500 mg (reference and generic). One of the generics presented a batch with form B and another one with form C. All the other tablets presented form A.
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Mebendazole, Polymorphism, Rietveld method, X-ray powder diffractometry
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Inglês
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Journal of the Brazilian Chemical Society, v. 26, n. 9, p. 1760-1768, 2015.
