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Antimalarial use of volatile oil from leaves of Virola surinamensis (Rol.) Warb. by Waiapi Amazon Indians

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dc.contributor.authorLopes, N. P.
dc.contributor.authorKato, M. J.
dc.contributor.authorAndrade, EHD
dc.contributor.authorMaia, JGS
dc.contributor.authorYoshida, M.
dc.contributor.authorPlanchart, A. R.
dc.contributor.authorKatzin, A. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMuseu Paraense Emilio Goeldi
dc.date.accessioned2014-05-20T15:20:16Z
dc.date.available2014-05-20T15:20:16Z
dc.date.issued1999-11-01
dc.description.abstractThe Amazon Indians Waiapi living in the West of Amapa State of Brazil, treat malaria with an inhalation of vapor obtained from leaves of Viola surinamensis. The essential oil obtained from adult and plantlet leaves was analyzed by GC/MS and 11 monoterpenes, 11 sesquiterpenes and three phenylpropanoids were identified. Plantlet essential oil caused 100% of growth inhibition after 48 h in the development of the young trophozoite to schizont stage and the sesquiterpene nerolidol (100 mu g/ml) was identified as one of the active constituents (100% of growth inhibition was obtained). In addition, examination of [(UC)-C-14]-glucose incorporation showed that activity of nerolidol is related to the inhibition of glycoprotein biosynthesis. (C) 1999 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14040903 Ribeirao Preto, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-05599970 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationMuseu Paraense Emilio Goeldi, BR-66040170 Belem, Para, Brazil
dc.description.affiliationUniv São Paulo, Inst Ciências Biomed, Dept Parasitol, BR-05508900 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
dc.format.extent313-319
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(99)00072-0
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 67, n. 3, p. 313-319, 1999.
dc.identifier.doi10.1016/S0378-8741(99)00072-0
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/11449/31608
dc.identifier.wosWOS:000083283800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectessential oilpt
dc.subjectmalariapt
dc.subjectMyristicaceaept
dc.subjectPlasmodium falciparumpt
dc.subjectVirola surinamensispt
dc.subjectWaiapi Indianspt
dc.titleAntimalarial use of volatile oil from leaves of Virola surinamensis (Rol.) Warb. by Waiapi Amazon Indiansen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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