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HPLC-ESIMSn Profiling, Isolation, Structural Elucidation, and Evaluation of the Antioxidant Potential of Phenolics from Paepalanthus geniculatus

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dc.contributor.authordo Amaral, Fabiano Pereira [UNESP]
dc.contributor.authorNapolitano, Assunta
dc.contributor.authorMasullo, Milena
dc.contributor.authorSantos, Lourdes Campaner dos [UNESP]
dc.contributor.authorFesta, Michela
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorPizza, Cosimo
dc.contributor.authorPiacente, Sonia
dc.contributor.institutionUniv Salerno
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:20:27Z
dc.date.available2014-05-20T14:20:27Z
dc.date.issued2012-04-01
dc.description.abstractThe methanol extract of the flowers of Paepalanthus geniculatus Kunth. showed radical-scavenging activity in the TEAC assay. An analytical approach based on HPLC:ESIMSn was applied to obtain the metabolite profile of this extract and led to the rapid identification of 19 polyphenolic compounds comprising flavonoids and naphthopyranones. The new naphthopyranone (10, 16), quercetagetin (1, 5, 7, 13), and galetine derivatives (9, 11, 17, 19), and a flavonol glucoside cyclodimer in the truxillate form (12), were identified. Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).en
dc.description.affiliationUniv Salerno, Dipartimento Sci Farmaceut & Biomed, I-84084 Fisciano, SA, Italy
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Organ Chem, Inst Chem, BR-14800900 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Organ Chem, Inst Chem, BR-14800900 São Paulo, Brazil
dc.format.extent547-556
dc.identifierhttp://dx.doi.org/10.1021/np200604k
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 75, n. 4, p. 547-556, 2012.
dc.identifier.doi10.1021/np200604k
dc.identifier.issn0163-3864
dc.identifier.lattes3538253640602977
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/26151
dc.identifier.wosWOS:000303220500004
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleHPLC-ESIMSn Profiling, Isolation, Structural Elucidation, and Evaluation of the Antioxidant Potential of Phenolics from Paepalanthus geniculatusen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
unesp.author.lattes3538253640602977
unesp.author.orcid0000-0003-3032-2556[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química