Aryltetralols from Holostylis reniformis and syntheses of lignan analogous

Abstract

Abstract Two new lignans, an aryltetralol and its methyl ether analogous, were isolated from Holostylis reniformis (Aristolochiaceae) together with futokadsurin C and (-)-8′-epi-aristoligone. The latter was also obtained as an enantiomeric mixture by synthesis and was transformed into aryltetralols and aryltetralenes that were subjected to chiral-HPLC separations. The compound structures were determined by spectroscopic methods. Several of these lignans had their antiplasmodial activity (against Plasmodium falciparum, W2 clone, anti-HRPII) and toxicity to mammalian kidney cells (MDL<inf>50</inf>) evaluated. (-)-Cyclogalgravin and (-)-aristoligol exhibited activity (IC<inf>50</inf> ∼ 10.8 and 8.4 μM, respectively), the latter exhibited lower toxicity.