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Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27

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dc.contributor.authorSilva, Gabriel
dc.contributor.authorLima, Felipe Teixeira
dc.contributor.authorSeba, Viviane
dc.contributor.authorMendes Lourenco, Ana Laura
dc.contributor.authorLucas, Thaise Graminha
dc.contributor.authorAndrade, Bianca Vieira de
dc.contributor.authorTorrezan, Guilherme Silva [UNESP]
dc.contributor.authorPolaquini, Carlos Roberto [UNESP]
dc.contributor.authorGarcia, Marcelo Engracia
dc.contributor.authorCouto, Lucelio Bernardes
dc.contributor.authorBestetti, Reinaldo Bulgarelli
dc.contributor.authorFranca, Suzelei de Castro
dc.contributor.authorFachin, Ana Lucia
dc.contributor.authorRegasini, Luis Octavio [UNESP]
dc.contributor.authorMarins, Mozart
dc.contributor.institutionUniv Ribeirao Preto
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:48:26Z
dc.date.available2018-11-26T17:48:26Z
dc.date.issued2018-02-01
dc.description.abstractGastric cancer is one of the most frequent malignant tumors in the world. The majority of patients are diagnosed with metastatic gastric cancer, which has a low survival rate. These data reinforce the importance of studying the anticancer activity of new molecules with the potential to suppress gastric cancer metastasis. Curcumin is a well-studied compound that has demonstrated anti-metastatic effects. Here we investigated if CH-5, a curcumin derivative compound, has anti-metastatic properties in the human gastric cancer cell line HGC-27. Firstly, we found that CH-5 decreased viability and induced apoptosis in HGC-27 cells in a dose-dependent manner. Additionally, CH-5 suppressed the migration and invasion of HGC-27 cells by downregulating the expression and collagenase activity of matrix metalloproteinase 2 in a dose-dependent manner. In conclusion, CH-5 showed anticancer activities, including the induction of apoptosis, and the suppression of migration and invasion in HGC-27 cells, suggesting that CH-5 can be a lead molecule for the development of anti-metastatic drugs for gastric cancer therapy.en
dc.description.affiliationUniv Ribeirao Preto, Biotechnol Unit, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Ribeirao Preto, Med Sch, Av Costabile Romano 2201, BR-14096900 Ribeirao Preto, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Green & Med Chem, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Green & Med Chem, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipMinistry of Education (Programa de Educacao Tutorial)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 471129/2013-5
dc.description.sponsorshipIdCNPq: 306251/2016-7
dc.description.sponsorshipIdFAPESP: 2014/18330-0
dc.description.sponsorshipIdFAPESP: 2014/15307-7
dc.description.sponsorshipIdFAPESP: 2017/03237-2
dc.format.extent10
dc.identifierhttp://dx.doi.org/10.3390/molecules23020279
dc.identifier.citationMolecules. Basel: Mdpi, v. 23, n. 2, 10 p., 2018.
dc.identifier.doi10.3390/molecules23020279
dc.identifier.fileWOS000426436300059.pdf
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/11449/163924
dc.identifier.wosWOS:000426436300059
dc.language.isoeng
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectgastric cancer
dc.subjectcurcumin
dc.subjectmatrix metalloproteinase 2
dc.subjectmigration
dc.subjectinvasion
dc.subjectapoptosis
dc.titleCurcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27en
dc.typeArtigo
dcterms.rightsHolderMdpi
dspace.entity.typePublication
unesp.author.orcid0000-0001-5913-0246[8]
unesp.author.orcid0000-0002-3705-0971[14]
unesp.author.orcid0000-0001-7389-4023[15]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentQuímica e Ciências Ambientais - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas