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Impact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineering

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dc.contributor.authorNunes, Fabio Caixeta
dc.contributor.authorSantos, Sarah Ingrid Pinto
dc.contributor.authorColnago, Luiz Alberto
dc.contributor.authorHammer, Peter [UNESP]
dc.contributor.authorFerreira, Julieta Adriana
dc.contributor.authorAmbrósio, Carlos Eduardo
dc.contributor.authorPallone, Eliria Maria Jesus Agnolon
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFundação Hermínio Ometto (FHO)
dc.date.accessioned2025-04-29T18:50:27Z
dc.date.issued2024-04-01
dc.description.abstractThis study investigates the profound impact of the ZrO2 inclusion volume on the characteristics of Al2O3/ZrO2 nanocomposites, particularly influencing the formation of calcium phosphates on the surface. This research, aimed at advancing tissue engineering, prepared nanocomposites with 5, 10, and 15 vol% ZrO2, subjecting them to chemical surface treatment for enhanced calcium phosphate deposition sites. Biomimetic coating with Sr-enriched simulated body fluid (SBF) further enhanced the bioactivity of nanocomposites. While the ZrO2 concentration heightened the oxygen availability on nanocomposite surfaces, the quantity of Sr-containing phosphate was comparatively less influenced than the formation of calcium phosphate phases. Notably, the coated nanocomposites exhibited a high cell viability and no toxicity, signifying their potential in bone tissue engineering. Overall, these findings contribute to the development of regenerative biomaterials, holding promise for enhancing bone regeneration therapies.en
dc.description.affiliationPostgraduate Programme in Materials Science and Engineering Faculty of Animal Science and Food Engineering (FZEA) University of São Paulo (USP), Av. Duque de Caxias Norte, 225, SP
dc.description.affiliationDepartment of Veterinary Medicine Faculty of Animal Science and Food Engineering (FZEA) University of São Paulo (USP), SP
dc.description.affiliationBrazilian Agricultural Research Corporation EMBRAPA Instrumentation, Rua Quinze de Novembro, 1500/1501, SP
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP), SP
dc.description.affiliationFundação Hermínio Ometto Fundação Hermínio Ometto (FHO), Av. Dr. Maximiliano Baruto, 500, SP
dc.description.affiliationDepartment of Biosystem Engineering Faculty of Animal Science and Food Engineering (FZEA) University of São Paulo (USP), SP
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.3390/ma17081893
dc.identifier.citationMaterials, v. 17, n. 8, 2024.
dc.identifier.doi10.3390/ma17081893
dc.identifier.issn1996-1944
dc.identifier.scopus2-s2.0-85191395195
dc.identifier.urihttps://hdl.handle.net/11449/300736
dc.language.isoeng
dc.relation.ispartofMaterials
dc.sourceScopus
dc.subjectalumina-zirconia
dc.subjectbiomaterial
dc.subjectcalcium phosphates
dc.subjectsurface treatment
dc.titleImpact of ZrO2 Content on the Formation of Sr-Enriched Phosphates in Al2O3/ZrO2 Nanocomposites for Bone Tissue Engineeringen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.author.orcid0000-0003-1309-7836[1]
unesp.author.orcid0000-0002-4655-3263[2]
unesp.author.orcid0000-0002-9516-9022[3]
unesp.author.orcid0000-0002-3823-0050[4]
unesp.author.orcid0000-0002-8224-5022[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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Araraquara - IQAR - Instituto de Química