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Interaction between the antimicrobial peptide Aurein 1.2 dimer and mannans

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dc.contributor.authorLorenzon, Esteban N. [UNESP]
dc.contributor.authorPiccoli, Julia P. [UNESP]
dc.contributor.authorCilli, Eduardo M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:53:00Z
dc.date.available2015-03-18T15:53:00Z
dc.date.issued2014-11-01
dc.description.abstractWe have previously described the structure and the ability of a dimeric analog of the antimicrobial peptide Aurein 1.2 to aggregate Candida albicans. In this study, circular dichroism and fluorescence spectroscopy data showed that this aggregation is related to the interaction between the peptide and mannans, the main component of yeast cell wall. In this context, we propose a model in which dimers interact with the polysaccharide leading to cells aggregation.en
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Chem, BR-14800060 Sao Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Chem, BR-14800060 Sao Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 12/15346-7
dc.format.extent2627-2631
dc.identifierhttp://dx.doi.org/10.1007/s00726-014-1832-x
dc.identifier.citationAmino Acids. Wien: Springer Wien, v. 46, n. 11, p. 2627-2631, 2014.
dc.identifier.doi10.1007/s00726-014-1832-x
dc.identifier.issn0939-4451
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.urihttp://hdl.handle.net/11449/116279
dc.identifier.wosWOS:000343995600016
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAmino Acids
dc.relation.ispartofjcr2.906
dc.relation.ispartofsjr1,135
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAurein 1.2en
dc.subjectDimerizationen
dc.subjectCandida albicansen
dc.subjectAggregationen
dc.subjectMannansen
dc.titleInteraction between the antimicrobial peptide Aurein 1.2 dimer and mannansen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.orcid0000-0002-4767-0904[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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Araraquara - IQAR - Instituto de Química