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Cell Therapy with Bone Marrow Mononuclear Cells in Elastase-Induced Pulmonary Emphysema

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dc.contributor.authorLonghini-dos-Santos, Nathalia
dc.contributor.authorBarbosa-de-Oliveira, Valter Abraão
dc.contributor.authorKozma, Rodrigo Heras
dc.contributor.authorde Faria, Carolina Arruda
dc.contributor.authorStessuk, Talita
dc.contributor.authorFrei, Fernando [UNESP]
dc.contributor.authorRibeiro-Paes, João Tadeu [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:28Z
dc.date.available2014-05-27T11:27:28Z
dc.date.issued2013-01-01
dc.description.abstractEmphysema is characterized by destruction of alveolar walls with loss of gas exchange surface and consequent progressive dyspnea. This study aimed to evaluate the efficiency of cell therapy with bone marrow mononuclear cells (BMMC) in an animal model of elastase-induced pulmonary emphysema. Emphysema was induced in C57Bl/J6 female mice by intranasal instillation of elastase. After 21 days, the mice received bone marrow mononuclear cells from EGFP male mice with C57Bl/J6 background. The groups were assessed by comparison and statistically significant differences (p & 0. 05) were observed among the groups treated with BMMC and evaluated after 7, 14 and 21 days. Analysis of the mean linear intercept (Lm) values for the different groups allowed to observe that the group treated with BMMC and evaluated after 21 days showed the most significant result. The group that received no treatment showed a statistically significant difference when compared to other groups, except the group treated and evaluated after 21 days, evidencing the efficacy of cell therapy with BMMC in pulmonary emphysema. © 2012 Springer Science+Business Media New York.en
dc.description.affiliationInter-units Program of Post-Graduation in Biotechnology University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP
dc.description.affiliationDepartment of Biological Sciences University of the State of São Paulo - UNESP, Assis, SP
dc.description.affiliationUnespDepartment of Biological Sciences University of the State of São Paulo - UNESP, Assis, SP
dc.format.extent210-218
dc.identifierhttp://dx.doi.org/10.1007/s12015-012-9419-y
dc.identifier.citationStem Cell Reviews and Reports, v. 9, n. 2, p. 210-218, 2013.
dc.identifier.doi10.1007/s12015-012-9419-y
dc.identifier.issn1550-8943
dc.identifier.issn1558-6804
dc.identifier.lattes4165274708509804
dc.identifier.scopus2-s2.0-84875623281
dc.identifier.urihttp://hdl.handle.net/11449/74151
dc.identifier.wosWOS:000317074300011
dc.language.isoeng
dc.relation.ispartofStem Cell Reviews and Reports
dc.relation.ispartofjcr3.612
dc.relation.ispartofsjr1,323
dc.relation.ispartofsjr1,323
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnimal model
dc.subjectCell therapy
dc.subjectCOPD
dc.subjectPulmonary emphysema
dc.subjectStem cells
dc.subjectbiological marker
dc.subjectpancreatic elastase
dc.subjectanimal
dc.subjectbone marrow cell
dc.subjectbone marrow transplantation
dc.subjectC57BL mouse
dc.subjectchemically induced disorder
dc.subjectchemistry
dc.subjectcytology
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunology
dc.subjectimmunophenotyping
dc.subjectlung
dc.subjectlung emphysema
dc.subjectlung lavage
dc.subjectmale
dc.subjectmetabolism
dc.subjectmononuclear cell
dc.subjectmouse
dc.subjectpathology
dc.subjecttransgenic mouse
dc.subjecttransplantation
dc.subjectAnimals
dc.subjectBiological Markers
dc.subjectBone Marrow Cells
dc.subjectBone Marrow Transplantation
dc.subjectBronchoalveolar Lavage Fluid
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunophenotyping
dc.subjectLeukocytes, Mononuclear
dc.subjectLung
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMice, Transgenic
dc.subjectPancreatic Elastase
dc.subjectPulmonary Emphysema
dc.subjectAnimalia
dc.subjectMus
dc.titleCell Therapy with Bone Marrow Mononuclear Cells in Elastase-Induced Pulmonary Emphysemaen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dspace.entity.typePublication
unesp.author.lattes4165274708509804
unesp.author.orcid0000-0002-3354-8430[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Letras, Assispt
unesp.departmentCiências Biológicas - FCLASpt

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