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Molecular models of protein kinase 6 from Plasmodium falciparum

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dc.contributor.authorManhani, K. K.
dc.contributor.authorArcuri, H. A.
dc.contributor.authorda Silveira, NJF
dc.contributor.authorUchoa, H. B.
dc.contributor.authorde Azevedo, W. F.
dc.contributor.authorCanduri, F.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:21Z
dc.date.available2014-05-20T15:27:21Z
dc.date.issued2005-12-01
dc.description.abstractCyclin-dependent kinases (CDKs) have been identified as potential targets for development of drugs, mainly against cancer. These studies generated a vast library of chemical inhibitors of CDKs, and some of these molecules can also inhibit kinases identified in the Plasmodium falciparum genome. Here we describe structural models for Protein Kinase 6 from P. falciparum (PfPK6) complexed with Roscovitine and Olomoucine. These models show clear structural evidence for differences observed in the inhibition, and may help designing inhibitors for PfPK6 generating new potential drugs against malaria.en
dc.description.affiliationUniv Estadual Paulista, Dept Fis, BR-15054000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fis, BR-15054000 São Paulo, Brazil
dc.format.extent42-48
dc.identifierhttp://dx.doi.org/10.1007/s00894-005-0002-1
dc.identifier.citationJournal of Molecular Modeling. New York: Springer, v. 12, n. 1, p. 42-48, 2005.
dc.identifier.doi10.1007/s00894-005-0002-1
dc.identifier.issn1610-2940
dc.identifier.urihttp://hdl.handle.net/11449/37353
dc.identifier.wosWOS:000233482800006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Molecular Modeling
dc.relation.ispartofjcr1.507
dc.relation.ispartofsjr0,360
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectkinasespt
dc.subjectbioinformaticspt
dc.subjectPlasmodium falciparumpt
dc.subjectRoscovitinept
dc.subjectOlomoucinept
dc.titleMolecular models of protein kinase 6 from Plasmodium falciparumen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentFísica - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas