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Inhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosa

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dc.contributor.authorLopes, FCM
dc.contributor.authorCalvo, T. R.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorCarlos, I. Z.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:23:08Z
dc.date.available2014-05-20T15:23:08Z
dc.date.issued2005-09-01
dc.description.abstractThe effects of Alchornea glandulosa ethyl acetate fraction (AGF) on hydrogen peroxide (H2O2), nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production in peritoneal macrophages activated with lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) were investigated. Analysis by thin layer chromatography (TLC) of AGF showed several constituents, including flavonoids, which may have anti-inflammatory activity. Inhibitory effects of the fraction in H2O2 and NO production ranged from 8.59 +/- 7.84% to 70.56 +/- 4.16% and from 16.06 +/- 3.65% to 38.73 +/- 3.90%, respectively. The TNF-alpha production was only partially inhibited in the tested concentrations (12.21 +/- 6.23%-15.16 +/- 0.96%). According to these results, it is suggested that AGF has anti-inflammatory activity. This medicinal plant may have therapeutic potential in the control of inflammatory disorders.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Anal Clin, BR-14801902 São Paulo, Brazil
dc.description.affiliationUNESP, Inst Quim, Dept Quim Organ, BR-14800900 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Dept Anal Clin, BR-14801902 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, Dept Quim Organ, BR-14800900 São Paulo, Brazil
dc.format.extent1726-1730
dc.identifierhttp://dx.doi.org/10.1248/bpb.28.1726
dc.identifier.citationBiological & Pharmaceutical Bulletin. Tokyo: Pharmaceutical Soc Japan, v. 28, n. 9, p. 1726-1730, 2005.
dc.identifier.doi10.1248/bpb.28.1726
dc.identifier.fileWOS000231774300036.pdf
dc.identifier.issn0918-6158
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/33973
dc.identifier.wosWOS:000231774300036
dc.language.isoeng
dc.publisherPharmaceutical Soc Japan
dc.relation.ispartofBiological & Pharmaceutical Bulletin
dc.relation.ispartofjcr1.694
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAlchornea glandulosapt
dc.subjectanti-inflammatory activitypt
dc.subjectflavonoidpt
dc.subjecthydrogen peroxidept
dc.subjectnitric oxidept
dc.subjectTNF-alphapt
dc.titleInhibition of hydrogen peroxide, nitric oxide and TNF-alpha production in peritoneal macrophages by ethyl acetate fraction from Alchornea glandulosaen
dc.typeArtigo
dcterms.licensehttp://bpb.pharm.or.jp/document/transfer.pdf
dcterms.rightsHolderPharmaceutical Soc Japan
dspace.entity.typePublication
unesp.author.orcid0000-0003-3032-2556[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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