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Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage

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dc.contributor.authorGuimarães, Natalia S.S.
dc.contributor.authorMello, Joyce C.
dc.contributor.authorPaiva, Juliana S.
dc.contributor.authorBueno, Paula C.P. [UNESP]
dc.contributor.authorBerretta, Andresa A.
dc.contributor.authorTorquato, Ricardo J.
dc.contributor.authorNantes, Iseli L.
dc.contributor.authorRodrigues, Tiago
dc.contributor.institutionUniversidade de Mogi das Cruzes (UMC)
dc.contributor.institutionResearch, Development and Innovation Laboratory of Apis Flora Indl. Coml. Ltda.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.date.accessioned2014-05-27T11:26:23Z
dc.date.available2014-05-27T11:26:23Z
dc.date.issued2012-03-01
dc.description.abstractBaccharis dracunculifolia DC (Asteraceae) is the main botanical source used by honeybees to produce Brazilian green propolis whose hepatoprotective properties have been already described. In this work we investigated the protective effects of the glycolic extract of B. dracunculifolia (GEBd) against oxidative stress in isolated rat liver mitochondria (RLM). The GEBd was prepared by fractionated percolation using propylene glycol as solvent. The total phenols and flavonoids, which are substances with recognized antioxidant action, were quantified in GEBd and the phytochemical analysis was carried out by HPLC. GEBd exhibited significant scavenger activity towards DPPH radicals and superoxide anions in a concentration-dependent manner, and also a Fe 2+ chelating activity. GEBd decreased the basal H 2O 2 generation and the Fe 2+- or t-BuOOH-induced ROS production in isolated mitochondria. Lipid oxidation of mitochondrial membranes, protein thiol groups and GSH oxidation were also prevented by GEBd. This shows that B. dracunculifolia exhibit potent antioxidant activity protecting liver mitochondria against oxidative damage and such action probably contribute to the antioxidant and hepatoprotective effects of green propolis. © 2011 Elsevier Ltd.en
dc.description.affiliationCentro Interdisciplinar de Investigação Bioquímica (CIIB) Universidade de Mogi das Cruzes (UMC)
dc.description.affiliationResearch, Development and Innovation Laboratory of Apis Flora Indl. Coml. Ltda.
dc.description.affiliationInstituto de Química Universidade Estadual Paulista (UNESP)
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP/USP)
dc.description.affiliationDepartamento de Bioquímica Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationCentro de Ciências Naturais e Humanas (CCNH) Universidade Federal do ABC (UFABC)
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista (UNESP)
dc.format.extent1091-1097
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2011.11.014
dc.identifier.citationFood and Chemical Toxicology, v. 50, n. 3-4, p. 1091-1097, 2012.
dc.identifier.doi10.1016/j.fct.2011.11.014
dc.identifier.file2-s2.0-84856478927.pdf
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.scopus2-s2.0-84856478927
dc.identifier.urihttp://hdl.handle.net/11449/73200
dc.language.isoeng
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectBaccharis dracunculifolia
dc.subjectFree radicals
dc.subjectHepatoprotection
dc.subjectMitochondria
dc.subjectOxidative stress
dc.subject1,1 diphenyl 2 picrylhydrazyl
dc.subjectantioxidant
dc.subjectBaccharis dracunculifolia extract
dc.subjectferrous ion
dc.subjectflavonoid
dc.subjectglutathione
dc.subjecthydrogen peroxide
dc.subjectphenol
dc.subjectplant extract
dc.subjectpropolis
dc.subjectpropylene glycol
dc.subjectscavenger
dc.subjectsuperoxide
dc.subjectthiol group
dc.subjectunclassified drug
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectBaccharis
dc.subjectbaccharis dracunculifolia
dc.subjectcell protection
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdown regulation
dc.subjectdrug mechanism
dc.subjectdrug potency
dc.subjecthigh performance liquid chromatography
dc.subjectiron chelation
dc.subjectlipid oxidation
dc.subjectliver mitochondrion
dc.subjectliver protection
dc.subjectmale
dc.subjectmitochondrial membrane
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectphytochemistry
dc.subjectrat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectChromatography, High Pressure Liquid
dc.subjectGlutathione
dc.subjectLipids
dc.subjectMale
dc.subjectMitochondria, Liver
dc.subjectOxidation-Reduction
dc.subjectOxidative Stress
dc.subjectPropolis
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSpectrophotometry, Ultraviolet
dc.subjectAsteraceae
dc.subjectRattus
dc.titleBaccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damageen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication

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