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Effects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older people

dc.contributor.authorZago, Anderson Saranz
dc.contributor.authorSilveira, Leonardo Reis
dc.contributor.authorKokubun, Eduardo [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:48:41Z
dc.date.accessioned2014-05-20T13:58:26Z
dc.date.available2013-09-30T18:48:41Z
dc.date.available2014-05-20T13:58:26Z
dc.date.issued2010-11-01
dc.description.abstractThe polymorphisms of endothelial nitric oxide synthase (eNOS) are associated with reduced eNOS activity. Aerobic exercise training (AEX) may influence resting nitric oxide (NO) production, oxidative stress and blood pressure. The purpose of this study was to investigate the effect of AEX on the relationship among blood pressure, eNOS gene polymorphism and oxidative stress in pre-hypertensive older people. 118 pre-hypertensive subjects (59 +/- A 6 years) had blood samples collected after a 12 h overnight fast for assessing plasma NO metabolites (NOx) assays, thiobarbituric acid reactive substances (T-BARS) and superoxide dismutase activity (ecSOD). eNOS polymorphism (T-786C and G-894T) was done by standard PCR methods. All people were divided according to the genotype results (G1: TT/GG, G2: TT/GT + TT, G3: TC + CC/GG, G4: TC + CC/GT + TT). All parameters were measured before and after 6 months of AEX (70% of VO(2 max)). At baseline, no difference was found in systolic and diastolic blood pressure, ecSOD and T-BARS activity. Plasma NOx levels were significantly different between G1 (19 +/- A 1 mu M) and G4 (14.2 +/- A 0.6 mu M) and between G2 (20.1 +/- A 1.7 mu M) and G4 (14.2 +/- A 0.6 mu M). Therefore, reduced NOx concentration in G4 group occurred only when the polymorphisms were associated, suggesting that these results are more related to genetic factors than NO-scavenging effect. After AEX, the G4 increased NOx values (17.2 +/- A 1.2 mu M) and decreased blood pressure. G1, G3 and G4 decreased T-BARS levels. These results suggest the AEX can modulate the NOx concentration, eNOS activity and the relationship among eNOS gene polymorphism, oxidative stress and blood pressure especially in C (T-786C) and T (G-894T) allele carriers.en
dc.description.affiliationUniv São Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14040900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUNESP, Dept Phys Educ, Rio Claro, Brazil
dc.description.affiliationUnespUNESP, Dept Phys Educ, Rio Claro, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 04/07779-4
dc.description.sponsorshipIdCNPq: 557967/2009-0
dc.format.extent825-832
dc.identifierhttp://dx.doi.org/10.1007/s00421-010-1568-6
dc.identifier.citationEuropean Journal of Applied Physiology. New York: Springer, v. 110, n. 4, p. 825-832, 2010.
dc.identifier.doi10.1007/s00421-010-1568-6
dc.identifier.issn1439-6319
dc.identifier.lattes3650843918755682
dc.identifier.orcid0000-0002-9404-3444
dc.identifier.urihttp://hdl.handle.net/11449/20756
dc.identifier.wosWOS:000283252700015
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Applied Physiology
dc.relation.ispartofjcr2.401
dc.relation.ispartofsjr1,186
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectNitric oxideen
dc.subjectPhysical exerciseen
dc.subjecteNOS polymorphismen
dc.subjectBlood pressureen
dc.subjectOxidative stressen
dc.subjectElderlyen
dc.titleEffects of aerobic exercise on the blood pressure, oxidative stress and eNOS gene polymorphism in pre-hypertensive older peopleen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes3650843918755682
unesp.author.lattes2980528637146416[1]
unesp.author.orcid0000-0002-9404-3444[3]
unesp.author.orcid0000-0002-0081-0797[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentEducação Física - IBpt

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