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Publicação:
Water-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica

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dc.contributor.authorRodriguez, Julie P. G.
dc.contributor.authorBernardi, Darlon I.
dc.contributor.authorGubiani, Juliana R.
dc.contributor.authorOliveira, Juliana Magalhaes de
dc.contributor.authorMorais-Urano, Raquel P.
dc.contributor.authorBertonha, Ariane F.
dc.contributor.authorBandeira, Karin F.
dc.contributor.authorBulla, Jairo I. Q.
dc.contributor.authorSette, Lara D. [UNESP]
dc.contributor.authorFerreira, Antonio G.
dc.contributor.authorBatista, Joao M.
dc.contributor.authorSilva, Thayna de Souza
dc.contributor.authorSantos, Raquel Alves dos
dc.contributor.authorMartins, Carlos H. G.
dc.contributor.authorLira, Simone P.
dc.contributor.authorCunha, Marcos G. da
dc.contributor.authorTrivella, Daniela B. B.
dc.contributor.authorGrazzia, Nathalia
dc.contributor.authorGomes, Natalia E. S.
dc.contributor.authorGadelha, Fernanda
dc.contributor.authorMiguel, Danilo C.
dc.contributor.authorCauz, Ana Carolina G.
dc.contributor.authorBrocchi, Marcelo
dc.contributor.authorBerlinck, Roberto G. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Franca
dc.contributor.institutionNatl Ctr Res Energy & Mat
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2020-12-10T19:48:12Z
dc.date.available2020-12-10T19:48:12Z
dc.date.issued2020-01-01
dc.description.abstractA new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites.en
dc.description.affiliationUniv Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro,Avenida 24-A,1515, Rio Claro, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Franca, Nucleo Pesquisa Ciencia & Tecnol, Ave Dr Armando Salles Oliveira,201 Pq Univ, BR-14404600 Franca, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Ciencias Exatas, Escola Super Agr Luiz de Queiroz, Agron, Ave Padua Dias 11,CP 9, BR-13418900 Piracicaba, SP, Brazil
dc.description.affiliationNatl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, BR-13083862 Campinas, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro,Avenida 24-A,1515, Rio Claro, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2013/50228-8
dc.description.sponsorshipIdFAPESP: 2016/21341-9
dc.description.sponsorshipIdFAPESP: 2017/06014-4
dc.description.sponsorshipIdFAPESP: 2013/23153-7
dc.description.sponsorshipIdFAPESP: 2016/16033-3
dc.format.extent55-65
dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.9b00635
dc.identifier.citationJournal Of Natural Products. Washington: Amer Chemical Soc, v. 83, n. 1, p. 55-65, 2020.
dc.identifier.doi10.1021/acs.jnatprod.9b00635
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/11449/196539
dc.identifier.wosWOS:000510076700009
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal Of Natural Products
dc.sourceWeb of Science
dc.titleWater-Soluble Glutamic Acid Derivatives Produced in Culture by Penicillium solitum IS1-A from King George Island, Maritime Antarcticaen
dc.typeArtigo
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentBioquímica e Microbiologia - IBpt

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Rio Claro - IB - Instituto de Biociências