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Acetylated DNA-damaging clerodane diterpenes from Casearia sylvestris

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dc.contributor.authorde Carvalho, PRF
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.authorYoung, MCM
dc.contributor.authorKingston, DGI
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Bot
dc.contributor.institutionVirginia Polytech Inst & State Univ
dc.date.accessioned2014-05-20T15:21:37Z
dc.date.available2014-05-20T15:21:37Z
dc.date.issued1998-11-01
dc.description.abstractIn addition to the known diterpene casearin G (1), two new clerodane diterpene casearins type, casearin S (2) and casearin T (3), were isolated from an acetylated bioactive CH2Cl2/MeOH extract from leaves of Casealia sylvestris. The diterpenes 1-3 exhibited moderate but selective activity towards the DNA-repair deficient yeast Saccharomyces cerevisiae mutants RAD 52YK and RS 321. The structures of 1-3 were established on the basis of NMR spectroscopic experiments (C) 1998 Elsevier B.V. Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationInst Bot, Secao Fisiol & Bioquim Plantas, BR-01051 São Paulo, Brazil
dc.description.affiliationVirginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.format.extent1659-1662
dc.identifierhttp://dx.doi.org/10.1016/S0031-9422(98)00249-0
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V., v. 49, n. 6, p. 1659-1662, 1998.
dc.identifier.doi10.1016/S0031-9422(98)00249-0
dc.identifier.issn0031-9422
dc.identifier.lattes1308042794786872
dc.identifier.lattes4484083685251673
dc.identifier.urihttp://hdl.handle.net/11449/32749
dc.identifier.wosWOS:000077480300027
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCasearia sylvestrispt
dc.subjectflacourtiaceaept
dc.subjectditerpenept
dc.subjectclerodanept
dc.subjectcasearinspt
dc.subjectDNA-damaging activitypt
dc.titleAcetylated DNA-damaging clerodane diterpenes from Casearia sylvestrisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes1308042794786872
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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