Publicação: Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu
Nenhuma Miniatura disponível
Data
2007-01-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Amer Chemical Soc
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
One new erythrinian alkaloid derivative, (+)-11 alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of H-1, C-13, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Journal of Natural Products. Washington: Amer Chemical Soc, v. 70, n. 1, p. 48-53, 2007.
