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Antiplasmodial Natural Products

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dc.contributor.authorNogueira, Claudio R. [UNESP]
dc.contributor.authorLopes, Lucia Maria Xavier [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:20:30Z
dc.date.available2014-05-20T14:20:30Z
dc.date.issued2011-03-01
dc.description.abstractMalaria is a human infectious disease that is caused by four species of Plasmodium. It is responsible for more than 1 million deaths per year. Natural products contain a great variety of chemical structures and have been screened for antiplasmodial activity as potential sources of new antimalarial drugs. This review highlights studies on natural products with antimalarial and antiplasmodial activity reported in the literature from January 2009 to November 2010. A total of 360 antiplasmodial natural products comprised of terpenes, including iridoids, sesquiterpenes, diterpenes, terpenoid benzoquinones, steroids, quassinoids, limonoids, curcubitacins, and lanostanes; flavonoids; alkaloids; peptides; phenylalkanoids; xanthones; naphthopyrones; polyketides, including halenaquinones, peroxides, polyacetylenes, and resorcylic acids; depsidones; benzophenones; macrolides; and miscellaneous compounds, including halogenated compounds and chromenes are listed in this review.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 555675/2009-2
dc.description.sponsorshipIdCNPq: 575746/2008-4
dc.format.extent2146-2190
dc.identifierhttp://dx.doi.org/10.3390/molecules16032146
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 16, n. 3, p. 2146-2190, 2011.
dc.identifier.doi10.3390/molecules16032146
dc.identifier.fileWOS000288853400017.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes5981353442037051
dc.identifier.urihttp://hdl.handle.net/11449/26161
dc.identifier.wosWOS:000288853400017
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectmalariaen
dc.subjectantimalarialen
dc.subjectantiplasmodialen
dc.subjectPlasmodiumen
dc.titleAntiplasmodial Natural Productsen
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
dspace.entity.typePublication
unesp.author.lattes5981353442037051
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química