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Potentiometric determination of alendronate in pharmaceutical formulations

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dc.contributor.authorMoreno, A. D.
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:29:51Z
dc.date.available2014-05-20T15:29:51Z
dc.date.issued2004-01-01
dc.description.abstractA simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 mug mL(-1). In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.en
dc.description.affiliationUNESP, Inst Quim, BR-14801970 Ararquara, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Quim, BR-14801970 Ararquara, SP, Brazil
dc.format.extent351-357
dc.identifierhttp://cat.inist.fr/?aModele=afficheN&cpsidt=15960297
dc.identifier.citationChemia Analityczna. Warsaw: Instytut Chemii Fizycznej Pan, v. 49, n. 3, p. 351-357, 2004.
dc.identifier.issn0009-2223
dc.identifier.lattes3192125098361121
dc.identifier.lattes5978908591853524
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.urihttp://hdl.handle.net/11449/39331
dc.identifier.wosWOS:000222768500007
dc.language.isoeng
dc.publisherInstytut Chemii Fizycznej Pan
dc.relation.ispartofChemia Analityczna
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpotentiometric determinationpt
dc.subjectalendronatept
dc.subjectpharmaceutical formulationspt
dc.titlePotentiometric determination of alendronate in pharmaceutical formulationsen
dc.typeArtigo
dcterms.rightsHolderInstytut Chemii Fizycznej Pan
dspace.entity.typePublication
unesp.author.lattes3192125098361121
unesp.author.lattes5978908591853524
unesp.author.orcid0000-0003-0197-7369[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Analítica - IQARpt

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Araraquara - IQAR - Instituto de Química