Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens
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Pharmaceutical Society of Japan
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Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC 50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. © 2008 Pharmaceutical Society of Japan.
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Antioxidant Flavone Myeloperoxidase Pterogyne nitens Radical scavenging flavone derivative glucoside myeloperoxidase nitensoside a nitensoside b pedalitin pedalitin 6 o beta glucopyranoside sorbifolin sorbifolin 6 o beta glucopyranoside controlled study drug inhibition drug structure IC 50 legume nonhuman nuclear magnetic resonance Benzothiazoles Enzyme Inhibitors Fabaceae Flavones Free Radical Scavengers Glucosides Magnetic Resonance Spectroscopy Peroxidase Picrates Plant Leaves Sulfonic Acids
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Inglês
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Chemical and Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, 2008.
