Publication:
New treatment strategies for Alzheimer's disease: is there a hope?

dc.contributor.authorAprahamian, Ivan
dc.contributor.authorStella, Florindo [UNESP]
dc.contributor.authorForlenza, Orestes V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:07:08Z
dc.date.available2014-12-03T13:07:08Z
dc.date.issued2013-10-01
dc.description.abstractAlzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease, and corresponds to the most common cause of dementia worldwide. Although not fully understood, the pathophysiology of AD is largely represented by the neurotoxic events triggered by the beta-amyloid cascade and by cytoskeletal abnormalities subsequent to the hyperphosphorylation of microtubule-associated Tau protein in neurons. These processes lead respectively to the formation of neuritic plaques and neurofibrillary tangles, which are the pathological hallmarks of the disease. Clinical benefits of the available pharmacological treatment for AD with antidementia drugs (namely cholinesterase inhibitors and memantine) are unquestionable, although limited to a temporary, symptomatic support to cognitive and related functions. Over the past decade, substantial funding and research have been dedicated to the search and development of new pharmaceutical compounds with disease-modifying properties. The rationale of such approach is that by tackling key pathological processes in AD it may be possible to attenuate or even change its natural history. In the present review, we summarize the available evidence on the new therapeutic approaches that target amyloid and Tau pathology in AD, focusing on pharmaceutical compounds undergoing phase 2 and phase 3 randomized controlled trials.en
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Neurosci LIM 27, BR-05403010 Sao Paulo, Brazil
dc.description.affiliationUNESP, Biosci Inst, Campus Of Rio Claro, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Campus Of Rio Claro, SP, Brazil
dc.format.extent449-460
dc.identifierhttp://www.ijmr.org.in/article.asp?issn=0971-5916;year=2013;volume=138;issue=4;spage=449;epage=460;aulast=Aprahamian;type=0
dc.identifier.citationIndian Journal of Medical Research. New Delhi: Indian Council Medical Res, v. 138, p. 449-460, 2013.
dc.identifier.fileWOS000330872300004.pdf
dc.identifier.issn0971-5916
dc.identifier.lattes7964386240653380
dc.identifier.urihttp://hdl.handle.net/11449/111277
dc.identifier.wosWOS:000330872300004
dc.language.isoeng
dc.publisherIndian Council Medical Res
dc.relation.ispartofIndian Journal Of Medical Research
dc.relation.ispartofjcr1.508
dc.relation.ispartofsjr0,656
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAlzheimer's diseaseen
dc.subjectantidementia drugen
dc.subjectbeta-amyloiden
dc.subjectcognitive impairmenten
dc.subjectTauen
dc.subjecttreatmenten
dc.titleNew treatment strategies for Alzheimer's disease: is there a hope?en
dc.typeArtigo
dcterms.rightsHolderIndian Council Medical Res
dspace.entity.typePublication
unesp.author.lattes7964386240653380
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentEducação - IBpt

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