Publication: Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation
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Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Sociedade Brasileira de Química
Type
Article
Access right
Acesso aberto
Abstract
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
Description
Keywords
amodiaquine, guanine, adduct
Language
English
Citation
Química Nova. Sociedade Brasileira de Química, v. 33, n. 6, p. 1291-1296, 2010.
