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Application of NiFe2O4 nanoparticles towards the detection of ovarian cancer marker

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dc.contributor.authorMaghiani, I. [UNESP]
dc.contributor.authorSouza, L.V.
dc.contributor.authorBach-Toledo, L.
dc.contributor.authorFaria, A.M.
dc.contributor.authorOrtega, P.P.
dc.contributor.authorAmoresi, R.A.C. [UNESP]
dc.contributor.authorSimões, A.Z. [UNESP]
dc.contributor.authorMazon, T.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)pt
dc.date.accessioned2026-08-25T11:24:41Z
dc.date.issued2024-09-01
dc.description.abstractIn this work, we explored the potential application of NiFe2O4 magnetic nanoparticles in sensing platforms due to their cost-effectiveness and good magnetic properties. The spinel-type metal oxide was prepared using the conventional hydrothermal synthesis method. The structural, morphological, and magnetic properties of the as-synthesized NiFe2O4 nanoparticles were discussed. The nanoparticles were functionalized with cystamine, glutaraldehyde, and PVDF and then modified with the CA 125 antibody to obtain the immunosensor. FTIR and electrochemical analyses reveal immobilization of the antibody on the surface of the NiFe2O4 magnetic nanoparticles. The immunosensor developed in this work was made on a printed circuit board, allowing it to be used as a point-of-care device. The immunosensor showed excellent stability, reproducibility, specificity, and selectivity. Our findings are of great significance for developing novel, high-performance point-of-care electrochemical biosensors to be applied in detecting the CA 125 antigen, a widely used biomarker for the prognosis of ovarian cancer.
dc.description.affiliationSchool of Engineering and Sciences, São Paulo State University (UNESP), Guaratinguetá, São Paulo, Brazil
dc.description.affiliationCentro de Tecnologia da Informação Renato Archer, CTI, Rod. D. Pedro I, KM 143.6, 13069-901 Campinas, SP, Brazil
dc.description.affiliationCenter for Development of Functional Materials (CDMF), Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil
dc.description.affiliationFederal University of ABC (UFABC), Center for Engineering, Modeling and Applied Social Sciences, Av. Dos Estados, 5001, 09210-580, Santo André, SP, Brazil
dc.description.affiliationUnespSchool of Engineering and Sciences, São Paulo State University (UNESP), Guaratinguetá, São Paulo, Brazil
dc.identifierhttps://app.dimensions.ai/details/publication/pub.1170534992
dc.identifier.dimensionspub.1170534992
dc.identifier.doi10.1016/j.materresbull.2024.112835
dc.identifier.issn0025-5408
dc.identifier.issn1873-4227
dc.identifier.orcid0000-0001-7978-7085
dc.identifier.orcid0000-0001-9055-0812
dc.identifier.orcid0000-0001-7313-4390
dc.identifier.orcid0000-0002-4254-1281
dc.identifier.orcid0000-0002-7523-6013
dc.identifier.orcid0000-0003-2535-2187
dc.identifier.orcid0000-0003-2491-079X
dc.identifier.urihttps://hdl.handle.net/11449/330132
dc.publisherElsevier
dc.relation.ispartofMaterials Research Bulletin; v. 177; p. 112835
dc.rights.accessRightsAcesso restritopt
dc.rights.sourceRightsclosed
dc.sourceDimensions
dc.titleApplication of NiFe2O4 nanoparticles towards the detection of ovarian cancer marker
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationa4071986-4355-47c3-a5a3-bd4d1a966e4f
relation.isOrgUnitOfPublication.latestForDiscoverya4071986-4355-47c3-a5a3-bd4d1a966e4f
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Engenharia e Ciências, Guaratinguetápt

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Guaratinguetá - FEG - Faculdade de Engenharia e Ciências