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pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications

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dc.contributor.authorVega-Chacón, Jaime [UNESP]
dc.contributor.authorArbeláez, María Isabel Amaya [UNESP]
dc.contributor.authorJorge, Janaina Habib [UNESP]
dc.contributor.authorMarques, Rodrigo Fernando C. [UNESP]
dc.contributor.authorJafelicci, Miguel [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T16:46:44Z
dc.date.available2018-12-11T16:46:44Z
dc.date.issued2017-08-01
dc.description.abstractA novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel. The surface modification in each step was confirmed by DRIFTS, TEM and zeta potential measurements. The hydrodynamic diameter of the nanosystems decreases as the pH value decreases. The nanosystems showed high colloidal stability in water and no cytotoxicity was detected, which make these nanosystems suitable for biomedical applications.en
dc.description.affiliationSão Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationSão Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Dentistry
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent366-373
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2017.03.244
dc.identifier.citationMaterials Science and Engineering C, v. 77, p. 366-373.
dc.identifier.doi10.1016/j.msec.2017.03.244
dc.identifier.file2-s2.0-85016477043.pdf
dc.identifier.issn0928-4931
dc.identifier.scopus2-s2.0-85016477043
dc.identifier.urihttp://hdl.handle.net/11449/169591
dc.language.isoeng
dc.relation.ispartofMaterials Science and Engineering C
dc.relation.ispartofsjr1,110
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectHydrogel
dc.subjectMagnetite nanoparticles
dc.subjectpH-responsive
dc.subjectPoly(aspartic acid)
dc.titlepH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applicationsen
dc.typeArtigopt
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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Araraquara - IQAR - Instituto de Química