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Ribifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activity

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dc.contributor.authorPinto, Meri Emili F. [UNESP]
dc.contributor.authorBatista, Joao M. [UNESP]
dc.contributor.authorKoehbach, Johannes
dc.contributor.authorGaur, Pratibha
dc.contributor.authorSharma, Abhinay
dc.contributor.authorNakabashi, Myna
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorGiesel, Guilherme M.
dc.contributor.authorVerli, Hugo
dc.contributor.authorGruber, Christian W.
dc.contributor.authorBlanch, Ewan W.
dc.contributor.authorTavares, Joseam F.
dc.contributor.authorSilva, Marcelo S. da
dc.contributor.authorGarcia, Celia R. S.
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Manchester
dc.contributor.institutionUniv Queensland
dc.contributor.institutionMed Univ Vienna
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.date.accessioned2015-10-22T06:15:57Z
dc.date.available2015-10-22T06:15:57Z
dc.date.issued2015-03-01
dc.description.abstractA new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Instituto de Química (IQ), BR-14800060 Araraquara, SP, Brasil
dc.description.affiliationUniv Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England
dc.description.affiliationUniv Manchester, Fac Life Sci, Manchester M1 7DN, Lancs, England
dc.description.affiliationUniv Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia
dc.description.affiliationMed Univ Vienna, Ctr Physiol &Pharmacol, A-1090 Vienna, Austria
dc.description.affiliationUniversidade de São Paulo (USP), Instituto de Biociências (IB), Departamento de Fisiologia, BR-05508900 São Paulo, Brasil
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Ctr Biotechnol, BR-91500970 Porto Alegre, RS, Brasil
dc.description.affiliationUniversidade Federal da Paraíba (UFPB), Lab Pharmaceut Technol, BR-58051970 João Pessoa, PB, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Instituto de Química (IQ), BR-14800060 Araraquara, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2010/52327-5
dc.description.sponsorshipIdFAPESP: 2013/07600-3
dc.description.sponsorshipIdCAPES: BEX: 9875/11-5
dc.description.sponsorshipIdFAPESP: 2011/22339-4
dc.description.sponsorshipIdFAPESP: 2012/13739-1
dc.format.extent374-380
dc.identifierhttp://pubs.acs.org/doi/abs/10.1021/np5007668
dc.identifier.citationJournal Of Natural Products. Washington: Amer Chemical Soc, v. 78, n. 3, p. 374-380, 2015.
dc.identifier.doi10.1021/np5007668
dc.identifier.issn0163-3864
dc.identifier.lattes9424346762460416
dc.identifier.lattes4484083685251673
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.urihttp://hdl.handle.net/11449/129612
dc.identifier.wosWOS:000352033900006
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal Of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleRibifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activityen
dc.typeArtigo
dcterms.rightsHolderAmer Chemical Soc
dspace.entity.typePublication
unesp.author.lattes9424346762460416
unesp.author.lattes4484083685251673
unesp.author.orcid0000-0002-4767-0904[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQARpt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química