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Molecular model for the binary complex of uropepsin and pepstatin

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dc.contributor.authorde Azevedo, W. F.
dc.contributor.authorCanduri, F.
dc.contributor.authorFadel, V
dc.contributor.authorTeodoro, LGVL
dc.contributor.authorHial, V
dc.contributor.authorGomes, RAS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionFMTM
dc.date.accessioned2014-05-20T15:25:28Z
dc.date.available2014-05-20T15:25:28Z
dc.date.issued2001-09-14
dc.description.abstractThe three-dimensional structure of human uropepsin complexed with pepstatin has been modelled using human pepsin as a template. Uropepsin is an aspartic proteinase from the urine, produced in the form of pepsinogen A in the gastric mucosa. The structure is bilobal, consisting of two predominantly beta -sheet lobes which, as observed in other aspartic proteinases, are related by a pseudo twofold axis. A structural comparison between binary complexes of pepsin:pepstatin and uropepsin:pepstatin is discussed. (C) 2001 Academic Press.en
dc.description.affiliationUNESP, IBILCE, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationInst Butantan, Ctr Appl Toxinol, BR-05503900 São Paulo, Brazil
dc.description.affiliationFMTM, Dept Ciências Biol, BR-38015050 Uberaba, MG, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent277-281
dc.identifierhttp://dx.doi.org/10.1006/bbrc.2001.5555
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc., v. 287, n. 1, p. 277-281, 2001.
dc.identifier.doi10.1006/bbrc.2001.5555
dc.identifier.issn0006-291X
dc.identifier.lattes2835029061696580
dc.identifier.urihttp://hdl.handle.net/11449/35884
dc.identifier.wosWOS:000171012600044
dc.language.isoeng
dc.publisherAcademic Press Inc.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.ispartofjcr2.559
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectaspartic proteinasept
dc.subjecturopepsinpt
dc.subjectpepstatinpt
dc.subjectcomplexpt
dc.subjectmodelpt
dc.subjectStructurept
dc.titleMolecular model for the binary complex of uropepsin and pepstatinen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc.
dspace.entity.typePublication
unesp.author.lattes2835029061696580
unesp.author.orcid0000-0001-6368-8955[3]
unesp.author.orcid0000-0002-5984-0712[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentFísica - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas