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Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

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dc.contributor.authorGhezzi, Silvia
dc.contributor.authorCooper, Lynsay
dc.contributor.authorRubio, Alicia
dc.contributor.authorPagani, Isabel
dc.contributor.authorCapobianchi, Maria Rosaria
dc.contributor.authorIppolito, Giuseppe
dc.contributor.authorPelletier, Julien [UNESP]
dc.contributor.authorMeneghetti, Maria Cecilia Z.
dc.contributor.authorLima, Marcelo A.
dc.contributor.authorSkidmore, Mark A.
dc.contributor.authorBroccoli, Vania
dc.contributor.authorYates, Edwin A.
dc.contributor.authorVicenzi, Elisa
dc.contributor.institutionIst Sci San Raffaele
dc.contributor.institutionKeele Univ
dc.contributor.institutionLazzaro Spallanzani Natl Inst Infect Dis
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Liverpool
dc.contributor.institutionCNR
dc.date.accessioned2018-11-26T15:43:51Z
dc.date.available2018-11-26T15:43:51Z
dc.date.issued2017-04-01
dc.description.abstractThe recent Zika virus (ZIKV) outbreak, which mainly affected Brazil and neighbouring states, demonstrated the paucity of information concerning the epidemiology of several flaviruses, but also highlighted the lack of available agents with which to treat such emerging diseases. Here, we show that heparin, a widely used anticoagulant, while exerting a modest inhibitory effect on Zika Virus replication, fully prevents virus-induced cell death of human neural progenitor cells (NPCs). (C) 2017 Elsevier B.V. All rights reserved.en
dc.description.affiliationIst Sci San Raffaele, Via Olgettina, I-20132 Milan, Italy
dc.description.affiliationKeele Univ, Sch Life Sci, Keele ST5 5BG, Staffs, England
dc.description.affiliationLazzaro Spallanzani Natl Inst Infect Dis, Rome, Italy
dc.description.affiliationUniv Estadual Paulista Julio de Mesquito Filho, Inst Biotecnol, BR-18607440 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Rua Tres de Maio, BR-04044020 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Liverpool, Dept Biochem, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
dc.description.affiliationCNR, CNR, Inst Neurosci, Milan, Italy
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquito Filho, Inst Biotecnol, BR-18607440 Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipBBSRC/EPSRC for a New Investigator Award
dc.description.sponsorshipKeele University for Seed Funding Award
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council
dc.description.sponsorshipIdFAPESP: 15/08782-3
dc.description.sponsorshipIdBBSRC/EPSRC for a New Investigator Award: BB/L023717/1
dc.description.sponsorshipIdBiotechnology and Biological Sciences Research Council: BB/L023717/1
dc.format.extent13-17
dc.identifierhttp://dx.doi.org/10.1016/j.antiviral.2016.12.023
dc.identifier.citationAntiviral Research. Amsterdam: Elsevier Science Bv, v. 140, p. 13-17, 2017.
dc.identifier.doi10.1016/j.antiviral.2016.12.023
dc.identifier.fileWOS000397076600002.pdf
dc.identifier.issn0166-3542
dc.identifier.urihttp://hdl.handle.net/11449/159451
dc.identifier.wosWOS:000397076600002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAntiviral Research
dc.relation.ispartofsjr1,925
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectZika virus (ZIKV)
dc.subjectNeural progenitor cells
dc.subjectHeparin
dc.subjectCell death
dc.titleHeparin prevents Zika virus induced-cytopathic effects in human neural progenitor cellsen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0002-1076-2979[6]
unesp.author.orcid0000-0003-4050-0926[11]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biotecnologia, Botucatupt

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Botucatu - IBTEC - Instituto de Biotecnologia