Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
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Coadvisor
Graduate program
Undergraduate course
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Publisher
Elsevier B.V.
Type
Article
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Acesso aberto
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Abstract
Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.
Description
Keywords
Antiparasitic agents, Molecular docking, Wasp venom, Mastoparan
Language
English
Citation
Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.
