Publicação: Triterpenes from maytenus macrocarpa and evaluation of their anti-hiv activity
| dc.contributor.author | Piacente, Sonia | |
| dc.contributor.author | Dos Santos, Lourdes Campaner [UNESP] | |
| dc.contributor.author | Mahmood, Naheed | |
| dc.contributor.author | Pizza, Cosimo | |
| dc.contributor.institution | University of Salerno | |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | |
| dc.contributor.institution | London Hospital | |
| dc.date.accessioned | 2022-04-28T18:55:44Z | |
| dc.date.available | 2022-04-28T18:55:44Z | |
| dc.date.issued | 2006-01-01 | |
| dc.description.abstract | A set of pentacyclic triterpenes has been isolated from the bark of Maytenus macrocarpa (Celastraceae). It includes two new olean-12-ene derivatives, namely 3β, 22α-dihydroxy-olean-12-en-30-oic acid (1) and 22α-hydroxy-olean-12-en-3-oxo-30-oic acid (2), and the new urs-12-ene derivative 3-(E)-coumaroyluvaol (7), along with 10 known compounds possessing olean-12- ene, urs-12-ene, lupane and friedelane skeletons. The structures have been elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments, as well as ESI-MS analysis. All isolated compounds were tested for anti-HIV activity in C8166 cells infected with HIV-1MN. The most active compound was 22α-hydroxy-12-en-3-oxo-29-oic acid (triterpenonic acid A, 4), with an EC50 value of 1 μg/mL and a selectivity index of 35. | en |
| dc.description.affiliation | Dipartimento di Scienze Farmaceutiche University of Salerno, via Ponte Don Melillo, 84084 Fisciano Salerno | |
| dc.description.affiliation | Instituto de Quimica UNESP, CP335, CEP, 14801-970 Araraquara, SP | |
| dc.description.affiliation | Retroscreen Ltd Academic Virology London Hospital, 64 Turner Street, London E1 2AD | |
| dc.description.affiliationUnesp | Instituto de Quimica UNESP, CP335, CEP, 14801-970 Araraquara, SP | |
| dc.format.extent | 1073-1078 | |
| dc.identifier | http://dx.doi.org/10.1177/1934578x0600101201 | |
| dc.identifier.citation | Natural Product Communications, v. 1, n. 12, p. 1073-1078, 2006. | |
| dc.identifier.doi | 10.1177/1934578x0600101201 | |
| dc.identifier.issn | 1555-9475 | |
| dc.identifier.issn | 1934-578X | |
| dc.identifier.scopus | 2-s2.0-48149086277 | |
| dc.identifier.uri | http://hdl.handle.net/11449/219466 | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Natural Product Communications | |
| dc.source | Scopus | |
| dc.subject | Anti-HIV activity | |
| dc.subject | Celastraceae | |
| dc.subject | Maytenus macrocarpa | |
| dc.subject | Pentacyclic triterpenes | |
| dc.title | Triterpenes from maytenus macrocarpa and evaluation of their anti-hiv activity | en |
| dc.type | Artigo | pt |
| dspace.entity.type | Publication | |
| unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara | pt |