Publicação: Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: Correlation of prognostic factors and clinical outcome
dc.contributor.author | Zuccari, Debora A. P. C. | |
dc.contributor.author | Pavam, Marcilia V. | |
dc.contributor.author | Terzian, Ana Carolina B. [UNESP] | |
dc.contributor.author | Pereira, Rodrigo S. | |
dc.contributor.author | Ruiz, Camila M. | |
dc.contributor.author | Andrade, Joanna Coelho | |
dc.contributor.institution | Faculdade de Medicina de São José do Rio Preto (FAMERP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Centro Universitário de Rio Preto | |
dc.contributor.institution | VETPAT-Laboratório de Patologia e Biologia Molecular Veterinária | |
dc.date.accessioned | 2014-05-27T11:23:31Z | |
dc.date.available | 2014-05-27T11:23:31Z | |
dc.date.issued | 2008-04-01 | |
dc.description.abstract | E-cadherin is a cell-cell adhesion molecule and low e-cadherin expression is related to invasiveness and may indicate a bad prognosis in mammary neoplasms. The expression of cell proliferation markers PCNA and especially Ki-67, has also proved to have a strong prognostic value in this tumor class. The expression of these markers was related to the clinical-pathological characteristics of 73 surgically removed mammary tumors in female dogs by immunohistochemistry. There was no statistical correlation between these markers and death by neoplasm, survival time and disease-free interval. However, the loss of e-cadherin expression and marked Ki-67 expression (p=0.016) were considered statistically significant for the diagnosis (p=0.032). When evaluated as independent factors, there was evidence of the relationship between the loss of e-cadherin expression and high PCNA expression with changes in the body status (divided into obese, normal and cachectic) of female dogs (p=0.030); there was also evidence of the relationship between pseudopregnancy and e-cadherin alone (p=0.021) and for ulceration and PCNA alone (p=0.035). The significant correlation between the markers expression and these well known prognostic factors used individually or in combination suggests their prognostic value in canine mammary tumors. | en |
dc.description.affiliation | Centro Regional de Bioterismo Faculdade de Medicina de São José do Rio Preto (Famerp), Av. Juscelino K. Oliveira 1220, Rua 07, Casa 140, São José do Rio Preto, SP 15091-450 | |
dc.description.affiliation | Médica Veterinária Autônoma Famerp, Av. Brigadeiro Faria Lima 5416, Vila São Pedro, São José do Rio Preto, SP 15090-000 | |
dc.description.affiliation | Instituto de Biociências, Letras e Ciências Exatas (Ibilce) Unesp-São José do Rio Preto, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, São José do Rio Preto, SP 15054-000 | |
dc.description.affiliation | Centro Universitário de Rio Preto, BR 153 Km 69, São José do Rio Preto, SP 15100-000 | |
dc.description.affiliation | VETPAT-Laboratório de Patologia e Biologia Molecular Veterinária, Rua Coronel Manuel Moraes 146, Campinas, SP 13073-022 | |
dc.description.affiliationUnesp | Instituto de Biociências, Letras e Ciências Exatas (Ibilce) Unesp-São José do Rio Preto, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, São José do Rio Preto, SP 15054-000 | |
dc.format.extent | 207-215 | |
dc.identifier | http://dx.doi.org/10.1590/S0100-736X2008000400003 | |
dc.identifier.citation | Pesquisa Veterinaria Brasileira, v. 28, n. 4, p. 207-215, 2008. | |
dc.identifier.doi | 10.1590/S0100-736X2008000400003 | |
dc.identifier.file | 2-s2.0-45849116447.pdf | |
dc.identifier.issn | 0100-736X | |
dc.identifier.issn | 1678-5150 | |
dc.identifier.scielo | S0100-736X2008000400003 | |
dc.identifier.scopus | 2-s2.0-45849116447 | |
dc.identifier.uri | http://hdl.handle.net/11449/70366 | |
dc.language.iso | eng | |
dc.relation.ispartof | Pesquisa Veterinária Brasileira | |
dc.relation.ispartofjcr | 0.385 | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | Scopus | |
dc.subject | Canine | |
dc.subject | Cell proliferation marker | |
dc.subject | E-cadherin | |
dc.subject | Immunohistochemistry | |
dc.subject | Mammary neoplasm | |
dc.subject | Canis familiaris | |
dc.title | Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: Correlation of prognostic factors and clinical outcome | en |
dc.type | Artigo | pt |
dcterms.license | http://www.scielo.br/revistas/pvb/paboutj.htm | |
dspace.entity.type | Publication | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto | pt |
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