Publicação:
Immunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: Correlation of prognostic factors and clinical outcome

dc.contributor.authorZuccari, Debora A. P. C.
dc.contributor.authorPavam, Marcilia V.
dc.contributor.authorTerzian, Ana Carolina B. [UNESP]
dc.contributor.authorPereira, Rodrigo S.
dc.contributor.authorRuiz, Camila M.
dc.contributor.authorAndrade, Joanna Coelho
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCentro Universitário de Rio Preto
dc.contributor.institutionVETPAT-Laboratório de Patologia e Biologia Molecular Veterinária
dc.date.accessioned2014-05-27T11:23:31Z
dc.date.available2014-05-27T11:23:31Z
dc.date.issued2008-04-01
dc.description.abstractE-cadherin is a cell-cell adhesion molecule and low e-cadherin expression is related to invasiveness and may indicate a bad prognosis in mammary neoplasms. The expression of cell proliferation markers PCNA and especially Ki-67, has also proved to have a strong prognostic value in this tumor class. The expression of these markers was related to the clinical-pathological characteristics of 73 surgically removed mammary tumors in female dogs by immunohistochemistry. There was no statistical correlation between these markers and death by neoplasm, survival time and disease-free interval. However, the loss of e-cadherin expression and marked Ki-67 expression (p=0.016) were considered statistically significant for the diagnosis (p=0.032). When evaluated as independent factors, there was evidence of the relationship between the loss of e-cadherin expression and high PCNA expression with changes in the body status (divided into obese, normal and cachectic) of female dogs (p=0.030); there was also evidence of the relationship between pseudopregnancy and e-cadherin alone (p=0.021) and for ulceration and PCNA alone (p=0.035). The significant correlation between the markers expression and these well known prognostic factors used individually or in combination suggests their prognostic value in canine mammary tumors.en
dc.description.affiliationCentro Regional de Bioterismo Faculdade de Medicina de São José do Rio Preto (Famerp), Av. Juscelino K. Oliveira 1220, Rua 07, Casa 140, São José do Rio Preto, SP 15091-450
dc.description.affiliationMédica Veterinária Autônoma Famerp, Av. Brigadeiro Faria Lima 5416, Vila São Pedro, São José do Rio Preto, SP 15090-000
dc.description.affiliationInstituto de Biociências, Letras e Ciências Exatas (Ibilce) Unesp-São José do Rio Preto, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, São José do Rio Preto, SP 15054-000
dc.description.affiliationCentro Universitário de Rio Preto, BR 153 Km 69, São José do Rio Preto, SP 15100-000
dc.description.affiliationVETPAT-Laboratório de Patologia e Biologia Molecular Veterinária, Rua Coronel Manuel Moraes 146, Campinas, SP 13073-022
dc.description.affiliationUnespInstituto de Biociências, Letras e Ciências Exatas (Ibilce) Unesp-São José do Rio Preto, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, São José do Rio Preto, SP 15054-000
dc.format.extent207-215
dc.identifierhttp://dx.doi.org/10.1590/S0100-736X2008000400003
dc.identifier.citationPesquisa Veterinaria Brasileira, v. 28, n. 4, p. 207-215, 2008.
dc.identifier.doi10.1590/S0100-736X2008000400003
dc.identifier.file2-s2.0-45849116447.pdf
dc.identifier.issn0100-736X
dc.identifier.issn1678-5150
dc.identifier.scieloS0100-736X2008000400003
dc.identifier.scopus2-s2.0-45849116447
dc.identifier.urihttp://hdl.handle.net/11449/70366
dc.language.isoeng
dc.relation.ispartofPesquisa Veterinária Brasileira
dc.relation.ispartofjcr0.385
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectCanine
dc.subjectCell proliferation marker
dc.subjectE-cadherin
dc.subjectImmunohistochemistry
dc.subjectMammary neoplasm
dc.subjectCanis familiaris
dc.titleImmunohistochemical evaluation of e-cadherin, Ki-67 and PCNA in canine mammary neoplasias: Correlation of prognostic factors and clinical outcomeen
dc.typeArtigopt
dcterms.licensehttp://www.scielo.br/revistas/pvb/paboutj.htm
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt

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