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Metabolic profile and safety of piperlongumine

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dc.contributor.authorMoreira, Fernanda de Lima
dc.contributor.authorHabenschus, Maisa D.
dc.contributor.authorBarth, Thiago
dc.contributor.authorMarques, Lucas M. M.
dc.contributor.authorPilon, Alan Cesar [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorVessecchi, Ricardo
dc.contributor.authorLopes, Norberto P.
dc.contributor.authorOliveira, Anderson R. M. de
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:06:22Z
dc.date.available2018-11-26T17:06:22Z
dc.date.issued2016-09-29
dc.description.abstractPiperlongumine (PPL), a natural plant product, has been extensively studied in cancer treatment going up on clinical trials. Since the first report related to its use on cancer research (in 2011) around 80 papers have been published in less than 10 years, but a gap still remaining. There are no metabolism studies of PPL in human organism. For the lack of a better view, here, the CYP450 in vitro oxidation of PPL was described for the first time. In addition, the enzymatic kinetic data, the predicted in vivo parameters, the produced metabolites, the phenotyping study and possible piperlongumine-drug interactions in vivo is presented.en
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Lab Prod Bioat, Campus Macae IMMT, BR-27930560 Macae, RJ, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynthesis & Ecophysiol Nat P, Araraquara, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Nucleo Pesquisa Prod Nat & Sintet NPPNS, BR-14040903 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynthesis & Ecophysiol Nat P, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipINCT-if
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipUniversity of Sao Paulo
dc.description.sponsorshipIdFAPESP: 2012/0188-4
dc.description.sponsorshipIdFAPESP: 2013/17658-9
dc.description.sponsorshipIdFAPESP: 2014/23604-1
dc.description.sponsorshipIdFAPESP: 2014/50265-3
dc.description.sponsorshipIdCNPq: 010143/2011-4
dc.description.sponsorshipIdCNPq: 442384/2014-9
dc.description.sponsorshipIdCNPq: 306385/2011-2
dc.description.sponsorshipIdUniversity of Sao Paulo: 2012.1.17587.1.1
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1038/srep33646
dc.identifier.citationScientific Reports. London: Nature Publishing Group, v. 6, 9 p., 2016.
dc.identifier.doi10.1038/srep33646
dc.identifier.fileWOS000384173600001.pdf
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11449/161967
dc.identifier.wosWOS:000384173600001
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofScientific Reports
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleMetabolic profile and safety of piperlongumineen
dc.typeArtigo
dcterms.rightsHolderNature Publishing Group
dspace.entity.typePublication
unesp.author.orcid0000-0001-8472-3190[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química