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Isolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarp

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dc.contributor.authorGontijo, Vanessa Silva
dc.contributor.authorde Souza, Thiago Correa
dc.contributor.authorRosa, Isael Aparecido
dc.contributor.authorSoares, Marisi Gomes
dc.contributor.authorda Silva, Marcelo Aparecido
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorViegas Junior, Claudio
dc.contributor.authordos Santos, Marcelo Henrique
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:34:43Z
dc.date.available2014-05-20T15:34:43Z
dc.date.issued2012-06-01
dc.description.abstractA new glycosylated biflavonone, morelloflavone-4 '''-O-beta-D-glycosyl, and the known compounds 1,3,6,7-tetrahydroxyxanthone, morelloflavone (fukugetin) and morelloflavone-7 ''-O-beta-D-glycosyl (fukugeside) were isolated from the epicarp of Garcinia brasiliensis collected in Brazil. The structures of these compounds were established using H-1 and C-13 NMR, COSY, gHMQC and gHMBC spectroscopy. The compounds exhibited antioxidant activity. The greatest potency was displayed by morelloflavone (2), with IC50 = 49.5 mM against DPPH and absorbance of 0.583 at 400 mu g/mL for the reduction of Fe3+. The weakest potency was displayed by 1,3,6,7-tetrahydroxyxanthone (1), with IC50 = 148 mM against DPPH and absorbance of 0.194 at 400 mu g/mL for the reduction of Fe3+. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Alfenas, Lab Fitoquim & Quim Med, Inst Quim Exatas, UNIFAL MG, Alfenas, MG, Brazil
dc.description.affiliationUniv Fed Alfenas, Lab Plantas Med & Fitoterapicos, Fac Ciencias Farmaceut, UNIFAL MG, Alfenas, MG, Brazil
dc.description.affiliationUNESP, Dept Quim Organ, Inst Quim Araraquara, Araraquara, Brazil
dc.description.affiliationUnespUNESP, Dept Quim Organ, Inst Quim Araraquara, Araraquara, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (FINEP)
dc.format.extent1230-1235
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2011.10.110
dc.identifier.citationFood Chemistry. Oxford: Elsevier B.V., v. 132, n. 3, p. 1230-1235, 2012.
dc.identifier.doi10.1016/j.foodchem.2011.10.110
dc.identifier.fileWOS000301022400016.pdf
dc.identifier.issn0308-8146
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/42633
dc.identifier.wosWOS:000301022400016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood Chemistry
dc.relation.ispartofjcr4.946
dc.relation.ispartofsjr1,793
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectGarcinia brasiliensisen
dc.subjectBiflavonoidsen
dc.subjectNatural productsen
dc.subjectAntioxidantsen
dc.titleIsolation and evaluation of the antioxidant activity of phenolic constituents of the Garcinia brasiliensis epicarpen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0003-3032-2556[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química