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Jatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: Isolation, characterization, conformational studies and biological activity

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dc.contributor.authorAltei, Wanessa F. [UNESP]
dc.contributor.authorPicchi, Douglas G. [UNESP]
dc.contributor.authorAbissi, Barbara M. [UNESP]
dc.contributor.authorGiesel, Guilherme M.
dc.contributor.authorFlausino, Otavio [UNESP]
dc.contributor.authorReboud-Ravaux, Michele
dc.contributor.authorVerli, Hugo
dc.contributor.authorCrusca, Edson [UNESP]
dc.contributor.authorSilveira, Edilberto R.
dc.contributor.authorCilli, Eduardo M. [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionUniv Paris 06
dc.contributor.institutionUniv Fed Ceara
dc.date.accessioned2015-03-18T15:53:58Z
dc.date.available2015-03-18T15:53:58Z
dc.date.issued2014-11-01
dc.description.abstractA cyclic peptide, jatrophidin I, was isolated from the latex of Jatropha curcas L. Its structure was elucidated by extensive 2D NMR spectroscopic analysis, with additional conformational studies performed using Molecular Dynamics/Simulated Annealing (MD/SA). Jatrophidin I had moderate protease inhibition activity when compared with pepstatin A; however, the peptide was inactive in antimalarial, cytotoxic and antioxidant assays. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Nucle Bioensaios Biossintese & Ecofisiol Prod Nat, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Ctr Biotecnol, BR-91500970 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Paris 06, Univ Paris 04, UR4, F-75252 Paris 05, France
dc.description.affiliationUniv Fed Rio Grande do Sul, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Bioquim & Biotecnol, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Nucle Bioensaios Biossintese & Ecofisiol Prod Nat, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Bioquim & Biotecnol, BR-14801970 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCNPq: 13/07600
dc.format.extent91-96
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2014.08.006
dc.identifier.citationPhytochemistry. Oxford: Pergamon-elsevier Science Ltd, v. 107, p. 91-96, 2014.
dc.identifier.doi10.1016/j.phytochem.2014.08.006
dc.identifier.issn0031-9422
dc.identifier.lattes4484083685251673
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.urihttp://hdl.handle.net/11449/116707
dc.identifier.wosWOS:000343840500010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectJatropha curcasen
dc.subjectEuphorbiaceaeen
dc.subjectCyclic peptidesen
dc.subjectProtease inhibition activityen
dc.titleJatrophidin I, a cyclic peptide from Brazilian Jatropha curcas L.: Isolation, characterization, conformational studies and biological activityen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes4484083685251673
unesp.author.orcid0000-0002-4767-0904[10]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQARpt
unesp.departmentQuímica Orgânica - IQARpt

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