Publicação:
Bioactive guanidine alkaloids from Pterogyne nitens

Página do item simplificado
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorGunatilaka, A. A. Leslie
dc.contributor.authorKingston, David G. I.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionVIRGINIA POLYTECH INST & STATE UNIV
dc.date.accessioned2014-05-27T11:18:02Z
dc.date.available2014-05-27T11:18:02Z
dc.date.issued1995-12-01
dc.description.abstractBioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).en
dc.description.affiliationDepartment of Chemistry Virginia Polytechnic Institute State University, Blacksburg, VA 24061-0212
dc.description.affiliationVirginia Polytechnic Institute State University
dc.description.affiliationInstituto de Quimica Universidade Estadual Paulista, CP. 355, 14800, Araraquara, SP
dc.description.affiliationUnespInstituto de Quimica Universidade Estadual Paulista, CP. 355, 14800, Araraquara, SP
dc.format.extent1683-1688
dc.identifierhttp://dx.doi.org/10.1021/np50125a006
dc.identifier.citationJournal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.
dc.identifier.doi10.1021/np50125a006
dc.identifier.issn0163-3864
dc.identifier.lattes4484083685251673
dc.identifier.scopus2-s2.0-0029610979
dc.identifier.urihttp://hdl.handle.net/11449/64664
dc.identifier.wosWOS:A1995TQ55100006
dc.language.isoeng
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectguanidine derivative
dc.subjectnitensidine
dc.subjectpterogynidine
dc.subjectpterogynine
dc.subjectunclassified drug
dc.subjectantineoplastic activity
dc.subjectbioassay
dc.subjectcarbon nuclear magnetic resonance
dc.subjectcytotoxicity
dc.subjectdna repair
dc.subjectdrug activity
dc.subjectdrug isolation
dc.subjectdrug structure
dc.subjectproton nuclear magnetic resonance
dc.titleBioactive guanidine alkaloids from Pterogyne nitensen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/paragonplus/copyright/jpa_form_a.pdf
dspace.entity.typePublication
unesp.author.lattes4484083685251673
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentQuímica Orgânica - IQARpt

Arquivos

Coleções

Araraquara - IQAR - Instituto de Química