Publicação: The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags
dc.contributor.author | Brentani, H. | |
dc.contributor.author | Caballero, O. L. | |
dc.contributor.author | Camargo, A. A. | |
dc.contributor.author | da Silva, A. M. | |
dc.contributor.author | da Silva, W. A. | |
dc.contributor.author | Neto, E. D. | |
dc.contributor.author | Grivet, M. | |
dc.contributor.author | Gruber, A. | |
dc.contributor.author | Guimaraes, PEM | |
dc.contributor.author | Hide, W. | |
dc.contributor.author | Iseli, C. | |
dc.contributor.author | Jongeneel, C. V. | |
dc.contributor.author | Kelso, J. | |
dc.contributor.author | Nagai, M. A. | |
dc.contributor.author | Ojopi, EPB | |
dc.contributor.author | Osorio, E. C. | |
dc.contributor.author | Reis, EMR | |
dc.contributor.author | Riggins, G. J. | |
dc.contributor.author | Simpson, AJG | |
dc.contributor.author | de Souza, S. | |
dc.contributor.author | Stevenson, B. J. | |
dc.contributor.author | Strausberg, R. L. | |
dc.contributor.author | Tajara, E. H. | |
dc.contributor.author | Verjovski-Almeida, S. | |
dc.contributor.author | Acencion, M. L. | |
dc.contributor.author | Bengtsono, M. H. | |
dc.contributor.author | Bettonip, F. | |
dc.contributor.author | Bodmerq, W. F. | |
dc.contributor.author | Brionesr, MRS | |
dc.contributor.author | Camargos, L. P. | |
dc.contributor.author | Caveneet, W. | |
dc.contributor.author | Ceruttiu, J. M. | |
dc.contributor.author | Coelho Andradev, L. E. | |
dc.contributor.author | Costa dos Santosn, P. C. | |
dc.contributor.author | Costaw, MCR | |
dc.contributor.author | da Silvaw, I. T. | |
dc.contributor.author | Esteciox, MRH | |
dc.contributor.author | Ferreiraw, K. S. | |
dc.contributor.author | Furnarit, F. B. | |
dc.contributor.author | Faria, M. | |
dc.contributor.author | Galantep, PAF | |
dc.contributor.author | Guimaraesy, G. S. | |
dc.contributor.author | Holandaw, A. J. | |
dc.contributor.author | Kimuraz, E. T. | |
dc.contributor.author | Leerkesp, M. R. | |
dc.contributor.author | Xin, L. A. | |
dc.contributor.author | Macielu, RMB | |
dc.contributor.author | Martinsbb, EAL | |
dc.contributor.author | Massirero, K. B. | |
dc.contributor.author | Melor, ASA | |
dc.contributor.author | Mestrinercc, C. A. | |
dc.contributor.author | Miraccan, E. C. | |
dc.contributor.author | Mirandas, L. L. | |
dc.contributor.author | Nobregadd, F. G. | |
dc.contributor.author | Oliveirap, P. S. | |
dc.contributor.author | Paquolaee, ACM | |
dc.contributor.author | Pandolficc, JRC | |
dc.contributor.author | Pardiniff, MIDC | |
dc.contributor.author | Passettip, F. | |
dc.contributor.author | Quackenbushgg, J. | |
dc.contributor.author | Schnabelr, B. | |
dc.contributor.author | Sogayaro, M. C. | |
dc.contributor.author | Souzap, J. E. | |
dc.contributor.author | Valentinicc, SR | |
dc.contributor.author | Zaiatsp, A. C. | |
dc.contributor.author | Amaralx, E. J. | |
dc.contributor.author | Arnaldiu, LAT | |
dc.contributor.author | de Araujow, A. G. | |
dc.contributor.author | de Bessan, S. A. | |
dc.contributor.author | Bicknellq, D. C. | |
dc.contributor.author | de Camaroy, MER | |
dc.contributor.author | Carrarop, D. M. | |
dc.contributor.author | Carrerhh, H. | |
dc.contributor.author | Carvalhop, A. F. | |
dc.contributor.author | Colino, C. | |
dc.contributor.author | Costaii, F. | |
dc.contributor.author | Curcioz, C. | |
dc.contributor.author | da Silvaw, IDCG | |
dc.contributor.author | da Silvav, N. P. | |
dc.contributor.author | Dellamanop, M. | |
dc.contributor.author | El-Dorrykk, H. | |
dc.contributor.author | Espreaficoll, E. M. | |
dc.contributor.author | Ferreirakk, AJS | |
dc.contributor.author | Ferreiraw, C. A. | |
dc.contributor.author | Fortesmm, MAHZ | |
dc.contributor.author | Gamann, A. H. | |
dc.contributor.author | Giannella-Netomm, D. | |
dc.contributor.author | Giannellamm, MLCC | |
dc.contributor.author | Giorgimm, R. R. | |
dc.contributor.author | Goldmanoo, G. H. | |
dc.contributor.author | Goldmanpp, MHS | |
dc.contributor.author | Hackely, C. | |
dc.contributor.author | Hobb, P. L. | |
dc.contributor.author | Kimuraqq, E. M. | |
dc.contributor.author | Kowalskirr, L. P. | |
dc.contributor.author | Kriegerss, J. E. | |
dc.contributor.author | Leitebb, LCC | |
dc.contributor.author | Lopesrr, A. | |
dc.contributor.author | Lunamm, AMSC | |
dc.contributor.author | Mackaytt, A. | |
dc.contributor.author | Marin, SKN | |
dc.contributor.author | Marquesw, A. A. | |
dc.contributor.author | Martinsp, W. K. | |
dc.contributor.author | Montagninirr, A. | |
dc.contributor.author | Netorr, M. M. | |
dc.contributor.author | Nascimentobb, ALTO | |
dc.contributor.author | Nevilleuu, A. M. | |
dc.contributor.author | Nobregadd, M. P. | |
dc.contributor.author | O'Harett, M. J. | |
dc.contributor.author | Otsukavv, A. Y. | |
dc.contributor.author | de Melop, AIR | |
dc.contributor.author | Paco-Larsonww, M. L. | |
dc.contributor.author | Pereiraii, G. G. | |
dc.contributor.author | Pereira da Silvav, N. | |
dc.contributor.author | Pesquerojj, J. B. | |
dc.contributor.author | Pessoajj, J. G. | |
dc.contributor.author | Rahal, Paula [UNESP] | |
dc.contributor.author | Rainhoxx, C. A. | |
dc.contributor.author | Rodriguesyy, V | |
dc.contributor.author | Rogatto, Silvia Regina [UNESP] | |
dc.contributor.author | Romanozz, C. M. | |
dc.contributor.author | Romeirox, J. G. | |
dc.contributor.author | Rossirr, B. M. | |
dc.contributor.author | Rusticcin, M. | |
dc.contributor.author | de Sayy, R. G. | |
dc.contributor.author | Sant' Annaqq, S. C. | |
dc.contributor.author | Sarmazox, M. L. | |
dc.contributor.author | de Lima e Silvay, T. C. | |
dc.contributor.author | Soaresrr, F. A. | |
dc.contributor.author | Sonatiqq, M. D. | |
dc.contributor.author | Sousall, J. D. | |
dc.contributor.author | Queirozy, D. | |
dc.contributor.author | Valenteww, V | |
dc.contributor.author | Vettorep, A. L. | |
dc.contributor.author | Villanovavv, F. E. | |
dc.contributor.author | Zagow, M. A. | |
dc.contributor.author | Zalcbergp, H. | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Ludwig Inst Canc Res | |
dc.contributor.institution | NCI | |
dc.contributor.institution | Duke Univ | |
dc.contributor.institution | Univ Western Cape | |
dc.contributor.institution | Ctr Estudo Telecomun PUC | |
dc.date.accessioned | 2014-05-20T15:29:43Z | |
dc.date.available | 2014-05-20T15:29:43Z | |
dc.date.issued | 2003-11-11 | |
dc.description.abstract | Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight against cancer, we have deposited some two million expressed sequence tags (ESTs) from human tumors and their corresponding normal tissues in the public databases. The data currently define approximate to23,500 genes, of which only approximate to1,250 are still represented only by ESTs. Examination of the EST coverage of known cancer-related (CR) genes reveals that <1% do not have corresponding ESTs, indicating that the representation of genes associated with commonly studied tumors is high. The careful recording of the origin of all ESTs we have produced has enabled detailed definition of where the genes they represent are expressed in the human body. More than 100,000 ESTs are available for seven tissues, indicating a surprising variability of gene usage that has led to the discovery of a significant number of genes with restricted expression, and that may thus be therapeutically useful. The ESTs also reveal novel nonsynonymous germline variants (although the one-pass nature of the data necessitates careful validation) and many alternatively spliced transcripts. Although widely exploited by the scientific community, vindicating our totally open source policy, the EST data generated still provide extensive information that remains to be systematically explored, and that may further facilitate progress toward both the understanding and treatment of human cancers. | en |
dc.description.affiliation | Univ São Paulo, Lab Genet Mol Canc, Dept Radiol, BR-05403010 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Dept Bioquim, Inst Quim, BR-05508900 São Paulo, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Dept Biol, Inst Biociencias, BR-15054 Sao Jose do Rio Preto, SP, Brazil | |
dc.description.affiliation | Ludwig Inst Canc Res, BR-01509010 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Dept Patol, Fac Med Vet & Zootecn, BR-05508000 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Fdn Hemocentro Ribeirao Preto, Fac Med Ribeirao Preto, BR-14051140 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | Univ São Paulo, Neurosci Lab, Inst Psiquiatria, Fac Med, BR-05403010 São Paulo, Brazil | |
dc.description.affiliation | NCI, Bethesda, MD 20892 USA | |
dc.description.affiliation | Duke Univ, Med Ctr, Durham, NC 27710 USA | |
dc.description.affiliation | Univ Western Cape, S African Natl Bioinformat Inst, ZA-7535 Bellville, South Africa | |
dc.description.affiliation | Ludwig Inst Canc Res, Off Informat Technol, CH-1066 Epalinges, Switzerland | |
dc.description.affiliation | Ctr Estudo Telecomun PUC, BR-22453900 Rio de Janeiro, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Biol, Inst Biociencias, BR-15054 Sao Jose do Rio Preto, SP, Brazil | |
dc.format.extent | 13418-13423 | |
dc.identifier | http://dx.doi.org/10.1073/pnas.1233632100 | |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America. Washington: Natl Acad Sciences, v. 100, n. 23, p. 13418-13423, 2003. | |
dc.identifier.doi | 10.1073/pnas.1233632100 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.lattes | 7991082362671212 | |
dc.identifier.orcid | 0000-0001-5693-6148 | |
dc.identifier.uri | http://hdl.handle.net/11449/39236 | |
dc.identifier.wos | WOS:000186573700056 | |
dc.language.iso | eng | |
dc.publisher | Natl Acad Sciences | |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | |
dc.relation.ispartofjcr | 9.504 | |
dc.relation.ispartofsjr | 6,092 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.title | The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags | en |
dc.type | Artigo | |
dcterms.license | http://www.pnas.org/site/misc/authorlicense.pdf | |
dcterms.rightsHolder | Natl Acad Sciences | |
dspace.entity.type | Publication | |
unesp.author.lattes | 7991082362671212[117] | |
unesp.author.orcid | 0000-0001-9249-4922[5] | |
unesp.author.orcid | 0000-0002-0728-4937[14] | |
unesp.author.orcid | 0000-0002-3922-1906[12] | |
unesp.author.orcid | 0000-0002-9556-3070[17] | |
unesp.author.orcid | 0000-0002-8621-3271[10] | |
unesp.author.orcid | 0000-0001-5192-4682[1] | |
unesp.author.orcid | 0000-0002-2603-2057[23] | |
unesp.author.orcid | 0000-0002-6076-9597[3] | |
unesp.author.orcid | 0000-0002-6356-2401[24] | |
unesp.author.orcid | 0000-0002-2296-2863[11] | |
unesp.author.orcid | 0000-0001-5824-5199[15] | |
unesp.author.orcid | 0000-0001-8093-2278[8] | |
unesp.author.orcid | 0000-0002-7530-600X[9] | |
unesp.author.orcid | 0000-0001-5693-6148[117] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Preto | pt |
unesp.department | Biologia - IBILCE | pt |
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