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Clavulanic acid production by immobilized cells of Streptomyces clavuligerus

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dc.contributor.authorLavarda, Susana Cristina Sperandei [UNESP]
dc.contributor.authorHokka, Carlos Osamu
dc.contributor.authorAraujo, Maria Lucia Gonsales Da Costa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2022-04-28T20:08:49Z
dc.date.available2022-04-28T20:08:49Z
dc.date.issued2006-09-20
dc.description.abstractA clavulanic acid production process with immobilized Streptomyces clavuligerus cells was investigated. Cells were immobilized in diatomaceous earth, calcium alginate gel as well as in the form of natural pellets and cultivated in shake flasks in a medium containing glycerol and soytone as the carbon and nitrogen sources, respectively. In all experiments growth occurred in the first 48 h and glycerol consumption after 72 h, while clavulanic acid production was observed between 48 and 60h, with gradual degradation after this period. The natural pellets presented higher product concentration as compared with the cells immobilized in supports. However, calcium alginate was found to be the best support in relation to cell retention capacity.en
dc.description.affiliationUniversidade Estadual Paulista - UNESP Depto. de Bioquímica e Tecnologia Química, P. O. Box 355, 14800-900, Araraquara -SP
dc.description.affiliationUniversidade Federal de São Carlos - UFSCar Departamento de Engenharia Química, C. P. 676, 13565-905, São Carlos - SP
dc.description.affiliationUnespUniversidade Estadual Paulista - UNESP Depto. de Bioquímica e Tecnologia Química, P. O. Box 355, 14800-900, Araraquara -SP
dc.format.extent125-131
dc.identifier.citationBrazilian Archives of Biology and Technology, v. 49, n. SPEC. ISS., p. 125-131, 2006.
dc.identifier.issn1516-8913
dc.identifier.scopus2-s2.0-33748637115
dc.identifier.urihttp://hdl.handle.net/11449/224799
dc.language.isoeng
dc.relation.ispartofBrazilian Archives of Biology and Technology
dc.sourceScopus
dc.subjectAlginate calcium gel
dc.subjectCelite
dc.subjectImmobilization cells
dc.subjectPellets
dc.subjectStreptomyces clavuligerus
dc.titleClavulanic acid production by immobilized cells of Streptomyces clavuligerusen
dc.typeTrabalho apresentado em evento
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentBioquímica e Tecnologia - IQpt

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Araraquara - IQAR - Instituto de Química