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Interaction of amphiphilic derivatives of chitosan with DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine)

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dc.contributor.authorde Oliveira Tiera, Vera Aparecida [UNESP]
dc.contributor.authorWinnik, Francoise M.
dc.contributor.authorTiera, Marcio Jose [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Montreal
dc.date.accessioned2014-05-20T14:03:05Z
dc.date.available2014-05-20T14:03:05Z
dc.date.issued2010-04-01
dc.description.abstractThe interaction of chitosan and its N-dodecyl and poly(ethylene glycol) derivatives with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) vesicles was studied to evaluate the influence of molecular architecture of the polymers on the liposomes. The study was carried out in aqueous solution using differential scanning microcalorimetry (DSC) and dynamic light scattering. The interaction of these polymers with DPPC vesicles altered the gel-liquid crystalline phase transition temperature and decreased both the enthalpy (Delta H) and cooperativity of the phase transition. The results obtained indicate that perturbations in the vesicles surface and the incorporation of chitosan and its derivatives into the lipid bilayer upon polysaccharides interaction are responsible for the formation of large vesicles.en
dc.description.affiliationUNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Quim & Ciencias Ambientais, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada
dc.description.affiliationUniv Montreal, Dept Chem, Montreal, PQ H3C 3J7, Canada
dc.description.affiliationUnespUNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Quim & Ciencias Ambientais, Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 07/00339-7
dc.format.extent309-313
dc.identifierhttp://dx.doi.org/10.1007/s10973-009-0375-y
dc.identifier.citationJournal of Thermal Analysis and Calorimetry. Dordrecht: Springer, v. 100, n. 1, p. 309-313, 2010.
dc.identifier.doi10.1007/s10973-009-0375-y
dc.identifier.issn1388-6150
dc.identifier.lattes8796747160088337
dc.identifier.urihttp://hdl.handle.net/11449/22231
dc.identifier.wosWOS:000276744500044
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Thermal Analysis and Calorimetry
dc.relation.ispartofjcr2.209
dc.relation.ispartofsjr0,587
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMicrocalorimetryen
dc.subjectLiposomesen
dc.subjectModified chitosansen
dc.subjectCoatingen
dc.subjectVesicle fusionen
dc.titleInteraction of amphiphilic derivatives of chitosan with DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine)en
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes8796747160088337
unesp.author.orcid0000-0002-5472-1482[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentQuímica e Ciências Ambientais - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas