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Synthesis of chitosan/hydroxyapatite membranes coated with hydroxycarbonate apatite for guided tissue regeneration purposes

dc.contributor.authorFraga, Alexandre Felix
dc.contributor.authorde Almeida Filho, Edson [UNESP]
dc.contributor.authorda Silva Rigo, Eliana Cristina
dc.contributor.authorBoschi, Anselmo Ortega
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T14:18:50Z
dc.date.available2014-05-20T14:18:50Z
dc.date.issued2011-02-15
dc.description.abstractChitosan, which is a non-toxic, biodegradable and biocompatible biopolymer, has been widely researched for several applications in the field of biomaterials. Calcium phosphate ceramics stand out among the so-called bioceramics for their absence of local or systemic toxicity, their non-response to foreign bodies or inflammations, and their apparent ability to bond to the host tissue. Hydroxyapatite (HA) is one of the most important bioceramics because it is the main component of the mineral phase of bone. The aim of this work was to produce chitosan membranes coated with hydroxyapatite using the modified biomimetic method. Membranes were synthesized from a solution containing 2% of chitosan in acetic acid (weight/volume) via the solvent evaporation method. Specimens were immersed in a sodium silicate solution and then in a 1.5 SBF (simulated body fluid) solution. The crystallinity of the HA formed over the membranes was correlated to the use of the nucleation agent (the sodium silicate solution itself). Coated membranes were characterized by means of scanning electron microscopy - SEM, X-ray diffraction - XRD, and Fourier transform infrared spectroscopy - FTIR. The results indicate a homogeneous coating covering the entire surface of the membrane and the production of a semi-crystalline hydroxyapatite layer similar to the mineral phase of human bone. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Dept Phys Chem IQ, Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Mat Engn, DEMa, UFSCar, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Basic Sci FZEA ZAB, Pirassununga, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Phys Chem IQ, Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent3888-3892
dc.identifierhttp://dx.doi.org/10.1016/j.apsusc.2010.11.104
dc.identifier.citationApplied Surface Science. Amsterdam: Elsevier B.V., v. 257, n. 9, p. 3888-3892, 2011.
dc.identifier.doi10.1016/j.apsusc.2010.11.104
dc.identifier.fileWOS000286459600014.pdf
dc.identifier.issn0169-4332
dc.identifier.urihttp://hdl.handle.net/11449/25680
dc.identifier.wosWOS:000286459600014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofApplied Surface Science
dc.relation.ispartofjcr4.439
dc.relation.ispartofsjr1,093
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectBiomimetic methoden
dc.subjectChitosanen
dc.subjectMembranes and hydroxyapatiteen
dc.titleSynthesis of chitosan/hydroxyapatite membranes coated with hydroxycarbonate apatite for guided tissue regeneration purposesen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscoverybc74a1ce-4c4c-4dad-8378-83962d76c4fd
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.departmentFísico-Química - IQARpt

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