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dc.contributor.authorBraz, Mariana Gobbo [UNESP]
dc.contributor.authorBraz, Leandro Gobbo [UNESP]
dc.contributor.authorBraz, José Reinaldo Cerqueira [UNESP]
dc.contributor.authorPierine, D. T. [UNESP]
dc.contributor.authorCorrêa, Camila Renata [UNESP]
dc.contributor.authorFerreira, A. L. [UNESP]
dc.contributor.authorCarvalho, L. R. [UNESP]
dc.contributor.authorYeum, K. J.
dc.contributor.authorSalvadori, D. M. [UNESP]
dc.date.accessioned2014-12-03T13:10:29Z
dc.date.available2014-12-03T13:10:29Z
dc.date.issued2013-09-01
dc.identifierhttp://www.minervamedica.it/en/journals/minerva-anestesiologica/article.php?cod=R02Y2013N09A1030
dc.identifier.citationMinerva Anestesiologica. Turin: Edizioni Minerva Medica, v. 79, n. 9, p. 1030-1038, 2013.
dc.identifier.issn0375-9393
dc.identifier.urihttp://hdl.handle.net/11449/112177
dc.description.abstractBackground. The effects of anesthetics on inflammation and oxidative parameters, evaluated in patients without morbidities undergoing undergoing minor surgery, remain unknown. The present study aimed to investigate the inflammatory and oxidative stress status in adult patients undergoing elective minimally invasive surgery, using different anesthetic techniques.Methods. Thirty patients classified as ASA physical status I, who were scheduled for minor surgeries (tympanoplasty or septoplasty), were randomly allocated into two groups: balanced (BAL) anesthesia maintained with isoflurane or total intravenous anesthesia (TIVA) with propofol. Blood samples were drawn prior to the induction of anesthesia (baseline), 120 mm after the beginning of anesthesia and one day after surgery. The proinflammatory cytokine IL-6 was determined by flow cytometry; DNA oxidation was evaluated by the single cell gel electrophoresis assay, and plasma malondialdehyde (lipid peroxidation biomarker) and antioxidant status were determined through fluorometry.Results. Increased IL-6 was observed one day after surgery in both groups (P=0.0001). Malondialdehyde levels did not change among the time points assessed or between the groups (P>0.05). Whereas BAL anesthesia had no effect on acid nucleic and antioxidant status, TIVA decreased oxidized/alkylated purines (P=0.03) and increased antioxidant status (P=0.002) during anesthesia. The two groups did not differ significantly in DNA oxidation or antioxidant status (P>0.05).Conclusion. BAL anesthesia maintained with isoflurane and TIVA maintained with propofol are safe by virtue of not causing oxidative stress status in ASA physical status I patients undergoing minimally invasive surgeries. Moreover, even in minor surgeries, TIVA with propofol produces an antioxidant effect in patients.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUNESP
dc.format.extent1030-1038
dc.language.isoeng
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofMinerva Anestesiologica
dc.sourceWeb of Science
dc.subjectAnestheticsen
dc.subjectGeneral surgeryen
dc.subjectInflammationen
dc.subjectAntioxidant agentsen
dc.titleComparison of oxidative stress in ASA physical status I patients scheduled for minimally invasive surgery under balanced or intravenous anesthesiaen
dc.typeArtigo
dcterms.rightsHolderEdizioni Minerva Medica
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionTufts Univ
dc.contributor.institutionKonkuk Univ
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Anesthesiol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biociencias Botucatu, Dept Biostat, Botucatu, SP, Brazil
dc.description.affiliationTufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA
dc.description.affiliationKonkuk Univ, Coll Biomed & Hlth Sci, Konkuk, South Korea
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Anesthesiol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biociencias Botucatu, Dept Biostat, Botucatu, SP, Brazil
dc.identifier.wosWOS:000327284200011
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 06/59625-6
dc.description.sponsorshipIdFAPESP: 10/05611-0
dc.description.sponsorshipIdFAPESP: 09/17344-9
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes6507858203899420
dc.identifier.lattes7199562550978496
dc.identifier.orcid0000-0003-4413-226X
unesp.author.lattes6507858203899420
unesp.author.lattes7199562550978496
unesp.author.orcid0000-0002-1927-8729[2]
unesp.author.orcid0000-0003-4413-226X[1]
dc.relation.ispartofjcr2.693
dc.relation.ispartofsjr0,763
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